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Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study.

Author: CarrazanaEnrique, MisraSunita N, RabinowiczAdrian L, SegalEric B, TarquinioDaniel, WhelessJames W

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This post hoc analysis of a long-term safety study evaluated the safety and effectiveness of diazepam nasal spray as rescue therapy for seizure clusters in patients with pediatric developmental epileptic encephalopathies. The analysis found a consistent safety profile across various developmental epileptic encephalopathies, supporting its use in these challenging patient populations.
Paper Details　
Original Abstract of the Article :
Pediatric developmental epileptic encephalopathies are often refractory to treatment despite stable antiseizure therapy. The safety profile of diazepam nasal spray (Valtoco) as rescue therapy for seizure clusters was described in a long-term safety study. This post hoc analysis assessed safety and e...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466939/

データ提供：米国国立医学図書館（NLM）

Diazepam Nasal Spray: A Safe Haven in the Desert of Developmental Epileptic Encephalopathies

This study explores the safety and efficacy of [diazepam nasal spray] as a [rescue therapy] for [seizure clusters] in children with [developmental epileptic encephalopathies]. Imagine a desert landscape where seizures are like unpredictable storms, leaving children vulnerable and distressed. Diazepam nasal spray is like a safe haven, providing immediate relief and reducing the frequency and severity of these storms.

A Safe and Effective Treatment Option

The study found that [diazepam nasal spray] demonstrated a [consistent safety profile] in children with [developmental epileptic encephalopathies]. The results suggest that this medication can be a valuable tool for managing seizures in these complex and challenging cases. The study also highlights the [effectiveness] of the medication, showing that it was able to effectively treat [seizure clusters] in the majority of patients.

Managing Seizures in Developmental Epileptic Encephalopathies

The study provides valuable insights into the management of [developmental epileptic encephalopathies]. It underscores the importance of having [safe and effective treatment options] available for these challenging conditions. The use of [diazepam nasal spray] can provide much-needed relief to children and their families, offering a sense of control and stability in their lives.

Dr. Camel's Conclusion

This study is like a cool oasis in the vast desert of [developmental epileptic encephalopathies], offering a safe and effective treatment option for children experiencing [seizure clusters]. The findings offer hope for families facing this challenge, highlighting the potential for [improved quality of life] with the use of [diazepam nasal spray].
Date :
  1. Date Completed 2023-08-25
  2. Date Revised 2023-09-01
Further Info :

Pubmed ID

37455404

DOI: Digital Object Identifier

PMC10466939

Related Literature

Article Analysis
・Effects of diazepam nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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