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Antimicrobial Resistance Profiling and Genome Analysis of the penA-60.001 Neisseria gonorrhoeae Clinical Isolates in China in 2021.

Author: ChenWentao, LiRongzhen, LinXiaomian, LiuXiaofeng, LuoXiaojuan, TangYingxian, ZhuangPeiqu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antimicrobial resistance rates of Neisseria gonorrhoeae are extremely high in China, particularly for ceftriaxone. The sustained transmission of penA-60.001 subclones poses a serious threat to treatment effectiveness.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Neisseria gonorrhoeae antimicrobial resistance (AMR) is an urgent public health threat. With dissemination of FC428-related clones, the efficacy of ceftriaxone has become controversial. METHODS: Agar dilution and whole genome sequencing were used to analyze AMR. RESULTS: High resistanc...See full text at original site
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引用元：
https://doi.org/10.1093/infdis/jiad258

データ提供：米国国立医学図書館（NLM）

Rising Antimicrobial Resistance: A Global Threat

The emergence of antimicrobial resistance is a pressing global health concern, like a relentless sandstorm sweeping across the world. This study, conducted in China, investigated the alarming levels of antimicrobial resistance in Neisseria gonorrhoeae, a common sexually transmitted infection. The authors used a combination of agar dilution and whole genome sequencing to analyze the antimicrobial resistance profiles of 463 isolates collected in China in 2021. They uncovered a concerning trend of high resistance to various antibiotics, including ceftriaxone, a crucial drug for treating gonorrhea.

The Spread of Resistant Strains

This study highlights the alarming spread of resistant strains of Neisseria gonorrhoeae. The authors found that a significant proportion of isolates, particularly those belonging to the penA-60.001 clone, exhibited resistance to ceftriaxone. These findings underscore the urgent need for global efforts to control the spread of antimicrobial resistance.

Protecting Public Health

The emergence of antimicrobial resistance poses a significant threat to public health. It is imperative to implement strategies to combat this challenge, such as responsible antibiotic use, robust surveillance systems, and the development of new antimicrobial drugs. These measures are crucial for safeguarding our ability to treat infectious diseases effectively.

Dr.Camel's Conclusion

Antimicrobial resistance is a growing threat, like a desert encroaching on fertile land. This study serves as a stark reminder of the importance of proactive measures to combat this global challenge.

Date :
  1. Date Completed 2023-09-18
  2. Date Revised 2023-09-22
Further Info :

Pubmed ID

37462263

DOI: Digital Object Identifier

10.1093/infdis/jiad258

Related Literature

Article Analysis
・Causes of gonorrhea
SNS
PICO Info
in preparation
Languages

English

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