Metabolites profiling and cheminformatics bioprospection of selected medicinal plants against the main protease and RNA-dependent RNA polymerase of SARS-CoV-2.

Author: Enitan-FolamiAbimbola Motunrayo, LanrewajuAdedayo Ayodeji, NyagaMartin M, SabiuSaheed, SwalahaFeroz Mahomed

Paper Details 
Original Abstract of the Article :
Despite the existence of some vaccines, SARS-CoV-2 (S-2) infections persist for various reasons relating to vaccine reluctance, rapid mutation rate, and an absence of specific treatments targeted to the infection. Due to their availability, low cost and low toxicity, research into potentially repurp...See full text at original site
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引用元:
https://doi.org/10.1080/07391102.2023.2236718

データ提供:米国国立医学図書館(NLM)

Medicinal Plants Against SARS-CoV-2: A Potential Oasis in the Pandemic Desert

The [fight against SARS-CoV-2] continues, and this research explores the potential of [phytometabolites] from [medicinal plants] as [antiviral agents]. The authors used [liquid chromatography-mass spectrometry (LCMS)] to identify [potential inhibitory agents] against [main protease (S-2 MP) and RNA-dependent RNA polymerase (RP)] of SARS-CoV-2. They utilized [computational approaches] such as [molecular docking and molecular dynamics simulations] to assess the [binding affinities and interactions] of these compounds with the target proteins. The research suggests that certain compounds, such as [quercetin 3-O-rhamnoside] and [ellagic acid hexoside], might exhibit [promising antiviral activity] against SARS-CoV-2.

Medicinal Plants Offer Hope in the Battle Against COVID-19

This research highlights the potential of [natural products] as [therapeutic agents] for COVID-19. The study suggests that certain compounds from medicinal plants could potentially [inhibit key proteins] involved in the virus's replication cycle, potentially [reducing viral load and disease severity].

Exploring the Power of Nature in Combating Disease

This research underscores the importance of [exploring natural resources] for [new therapeutic options] in the fight against infectious diseases. It also highlights the potential of [computational methods] for [rapidly screening and identifying] promising drug candidates.

Dr. Camel's Conclusion

This research, like a rare desert bloom, offers hope and potential solutions in the ongoing battle against SARS-CoV-2. The findings suggest that medicinal plants could provide a valuable source of new antiviral agents, highlighting the importance of exploring nature's bounty for therapeutic discoveries.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-07-19
Further Info :

Pubmed ID

37464870

DOI: Digital Object Identifier

10.1080/07391102.2023.2236718

Related Literature

SNS
PICO Info
in preparation
Languages

English

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