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Metabolites profiling and cheminformatics bioprospection of selected medicinal plants against the main protease and RNA-dependent RNA polymerase of SARS-CoV-2.
Author: Enitan-FolamiAbimbola Motunrayo, LanrewajuAdedayo Ayodeji, NyagaMartin M, SabiuSaheed, SwalahaFeroz Mahomed
Original Abstract of the Article :
Despite the existence of some vaccines, SARS-CoV-2 (S-2) infections persist for various reasons relating to vaccine reluctance, rapid mutation rate, and an absence of specific treatments targeted to the infection. Due to their availability, low cost and low toxicity, research into potentially repurp...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1080/07391102.2023.2236718
データ提供:米国国立医学図書館(NLM)
Medicinal Plants Against SARS-CoV-2: A Potential Oasis in the Pandemic Desert
The [fight against SARS-CoV-2] continues, and this research explores the potential of [phytometabolites] from [medicinal plants] as [antiviral agents]. The authors used [liquid chromatography-mass spectrometry (LCMS)] to identify [potential inhibitory agents] against [main protease (S-2 MP) and RNA-dependent RNA polymerase (RP)] of SARS-CoV-2. They utilized [computational approaches] such as [molecular docking and molecular dynamics simulations] to assess the [binding affinities and interactions] of these compounds with the target proteins. The research suggests that certain compounds, such as [quercetin 3-O-rhamnoside] and [ellagic acid hexoside], might exhibit [promising antiviral activity] against SARS-CoV-2.
Medicinal Plants Offer Hope in the Battle Against COVID-19
This research highlights the potential of [natural products] as [therapeutic agents] for COVID-19. The study suggests that certain compounds from medicinal plants could potentially [inhibit key proteins] involved in the virus's replication cycle, potentially [reducing viral load and disease severity].
Exploring the Power of Nature in Combating Disease
This research underscores the importance of [exploring natural resources] for [new therapeutic options] in the fight against infectious diseases. It also highlights the potential of [computational methods] for [rapidly screening and identifying] promising drug candidates.
Dr. Camel's Conclusion
This research, like a rare desert bloom, offers hope and potential solutions in the ongoing battle against SARS-CoV-2. The findings suggest that medicinal plants could provide a valuable source of new antiviral agents, highlighting the importance of exploring nature's bounty for therapeutic discoveries.
Date :
- Date Completed n.d.
- Date Revised 2023-07-19
Further Info :
Related Literature
English
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