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A Systematic Review and Meta-Analysis of Injection Site Reactions in Randomized-Controlled Trials of Biologic Injections.

Author: KimPatrick J, LansangRafael Paolo, VenderRon

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review summarizes injection site reaction data in phase 3 trials of all biologic agents. Injection site reactions are common, with erythema, unspecified reaction, pain, and pruritus being the most frequent. Canakinumab, Dupilumab, Etanercept, and Ixekizumab had the highest prevalence of injection site reactions, while Risankizumab, Brodalumab, Guselkumab, and Secukinumab had the lowest. No patients discontinued treatment due to injection site reactions in 39 of the 48 studies. The review recommends improving adverse event reporting to better understand the epidemiology of injection site reactions.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Biologic agents are emerging as an important treatment option for immune-mediated diseases. Injection site reactions following subcutaneous injection of biologic agents is not well described in the literature. OBJECTIVE: To summarize injection site reaction data in phase 3 trials of all...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486173/

データ提供：米国国立医学図書館（NLM）

Injection Site Reactions: A Journey Through the Desert of Biologics

The vast landscape of immune-mediated diseases is constantly evolving, with biologic agents emerging as a beacon of hope. However, the journey through this therapeutic desert isn't always smooth, and injection site reactions are a common side effect. This research, a systematic review and meta-analysis of phase 3 trials, delves into the prevalence of these reactions, shedding light on the safety and efficacy of biologics.

The authors meticulously sifted through 158 articles, analyzing data from 80 eligible studies. They found that the most frequent injection site reactions were erythema, unspecified reactions, pain, and pruritus. The prevalence of these reactions varied significantly across different biologics. Canakinumab, Dupilumab, Etanercept, and Ixekizumab emerged as the top four with the highest prevalence, while Risankizumab, Brodalumab, Guselkumab, and Secukinumab had the lowest. This research emphasizes the importance of comprehensive adverse event reporting to better understand the intricate dynamics of injection site reactions.

Navigating the Desert of Side Effects: Insights from a Comprehensive Review

This review provides a valuable roadmap for navigating the desert of potential side effects associated with biologic agents. The findings highlight the need for a nuanced approach to patient care, considering both the benefits and risks of each specific biologic.

A Desert Oasis for Informed Decisions: Understanding Biologics

As a patient, it's crucial to have a clear understanding of potential side effects. This research empowers you to engage in informed conversations with your healthcare provider, ensuring that you receive the best possible treatment for your individual needs. We can think of it as finding an oasis of clarity in the vast desert of medical decisions.

Dr. Camel's Conclusion

This study reminds us that even in the desert of medicine, where treatments are constantly evolving, it's essential to navigate with caution and knowledge. The authors' insightful exploration of injection site reactions provides valuable insights for both patients and healthcare providers, ultimately contributing to safer and more effective treatments.

Date :
  1. Date Completed 2023-11-02
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37533141

DOI: Digital Object Identifier

PMC10486173

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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