Switchable adhesive films of pullulan loaded with a deep eutectic solvent-curcumin formulation for the photodynamic treatment of drug-resistant skin infections.

Switchable Adhesive Films: A New Approach to Photodynamic Therapy for Skin Infections

Antimicrobial resistance, a growing desert of pathogens, is a formidable challenge. This research explores a new approach to photodynamic therapy (aPDT) using switchable adhesive films loaded with curcumin, a natural photosensitizer. The films are designed to transform from solid to adhesive hydrogel upon contact with skin moisture, extending the residence time of the photosensitizer and enhancing its effectiveness. It's like having a camel that can adapt to different terrain, transforming from a swift desert runner to a sturdy pack animal.

Switchable Adhesive Films: Enhanced Delivery and Efficacy

The study demonstrates that these switchable films exhibit higher extensibility and adhesiveness compared to traditional pullulan films. The curcumin-loaded hydrogels effectively inactivate multiresistant strains of Staphylococcus aureus in ex vivo skin samples, down to the detection limit. It's like having a camel that can navigate treacherous sand dunes with its flexible body and strong hooves, ensuring a safe and efficient delivery of its precious cargo.

A Promising Tool for Skin Infections

These non-cytotoxic, easily removable films offer a promising new tool for aPDT in the treatment of resistant skin infections. It's like having a camel that can not only transport goods but also heal wounds, making it a versatile and valuable asset in the desert of antimicrobial resistance.

Dr.Camel's Conclusion

This research introduces a novel approach to aPDT using switchable adhesive films loaded with curcumin. The films offer enhanced delivery and efficacy, making them a promising tool for the treatment of resistant skin infections.