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Real-life comparison of mortality in patients with SARS-CoV-2 infection at risk for clinical progression treated with molnupiravir or nirmatrelvir plus ritonavir during the Omicron era in Italy: a nationwide, cohort study.
Author: BassettiMatteo, BiagettiCarlo, BonfantiPaolo, BuccolieroGiovanni Battista, CacopardoBruno, CelantSimone, Di PerriGiovanni, ErneElke Maria, FrontutoMaria, GiacomettiAndrea, LanzafameMassimiliano, NicastriEmanuele, OlimpieriPier Paolo, PalùGiorgio, ParrutiGiustino, PerrellaAlessandro, RussoPierluigi, SpagnoliAlessandra, SummaValentina, TacconelliEvelina, TacconiDanilo, TasciniCarlo, TortiCarlo, VestriAnnarita
Original Abstract of the Article :
BACKGROUND: Comparative data on mortality in COVID-19 patients treated with molnupiravir or with nirmatrelvir plus ritonavir are inconclusive. We therefore compared all-cause mortality in community-dwelling COVID-19 patients treated with these drugs during the Omicron era. METHODS: Data collected i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398591/
データ提供：米国国立医学図書館（NLM）
Navigating the Omicron Era: Comparing COVID-19 Treatment Strategies
The [COVID-19 pandemic] has brought unprecedented challenges to healthcare systems worldwide. This research compares the [mortality rates] of two antiviral treatments, [molnupiravir and nirmatrelvir plus ritonavir], in COVID-19 patients at risk for clinical progression during the Omicron era. This study aims to evaluate the relative efficacy of these treatments in reducing mortality during a period of significant viral evolution.
Nirmatrelvir Plus Ritonavir: A Promising Advantage
The study's findings reveal that early initiation of nirmatrelvir plus ritonavir was associated with a significantly reduced risk of all-cause mortality by day 28 compared to molnupiravir. This suggests that nirmatrelvir plus ritonavir might be a more effective treatment option for COVID-19 patients at risk for clinical progression, especially during the Omicron era.
A New Horizon in COVID-19 Treatment: Navigating the Omicron Era
The study's findings offer valuable insights into the evolving landscape of COVID-19 treatment. The effectiveness of nirmatrelvir plus ritonavir in reducing mortality, particularly during the Omicron era, is encouraging. This research provides valuable guidance for clinicians seeking to optimize treatment strategies for COVID-19 patients and improve their chances of recovery.
Dr.Camel's Conclusion
As a researcher navigating the ever-changing desert of COVID-19 research, I'm continuously amazed by the rapid advancements in treatment strategies. This study provides valuable insights into the potential benefits of nirmatrelvir plus ritonavir in reducing mortality during the Omicron era. This research underscores the importance of ongoing research and clinical innovation in combatting this global health challenge, ultimately aiming to improve patient outcomes and safeguard public health.
Date :
- Date Completed n.d.
- Date Revised 2023-08-08
Further Info :
Related Literature
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