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Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy.

Author: MoonahShannon, ShirleyDebbie-Ann, TornelWilliam, WarrenCirle A

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Clostridioides difficile infection (CDI) is a significant concern in children, with increasing incidence and a spectrum of severity. While metronidazole remains a mainstay therapy, oral vancomycin and fidaxomicin are emerging alternatives, and fecal microbiota transplantation is gaining traction for recurrent CDI. This review highlights the unique challenges and advancements in managing CDI in children.
Paper Details　
Original Abstract of the Article :
Clostridioides (formerly Clostridium) difficile is the most important infectious cause of antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated infection in the United States. The incidence of C. difficile infection (CDI) in children has increased, with 20 000 cases n...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471512/

データ提供：米国国立医学図書館（NLM）

Clostridioides difficile Infection in Children: A Growing Concern

This review provides a comprehensive overview of the epidemiology, diagnosis, and treatment of Clostridioides difficile infection (CDI) in children, a condition that is increasingly affecting this vulnerable population. The authors address the rising incidence of CDI in children, highlighting the unique challenges posed by this infection in young patients, including the increased prevalence of community-associated CDI and the potential for severe disease. The review covers the latest advancements in diagnosis and treatment, including the limitations of existing diagnostic tests and the emergence of new therapeutic options, such as fecal microbiota transplantation.

Navigating the Challenges of CDI in Children

This research provides valuable insights into the challenges of diagnosing and treating CDI in children. The study underscores the need for accurate and timely diagnosis to ensure effective treatment and prevent complications. The authors highlight the importance of new diagnostic tests and biomarkers that can distinguish between colonization and infection, which is crucial for appropriate management. The research also emphasizes the growing role of fecal microbiota transplantation in managing recurrent CDI.

Protecting Children: Improving CDI Diagnosis and Treatment

This research calls for continued efforts to improve the diagnosis and treatment of CDI in children. The authors emphasize the need for new and better diagnostic tools to ensure accurate and timely diagnosis. The research also highlights the promise of fecal microbiota transplantation as a potential solution for managing recurrent CDI. The study reminds us that caring for children is a delicate dance, requiring a deep understanding of the unique challenges they face and a commitment to developing innovative solutions to protect their health.

Dr.Camel's Conclusion

This research offers an insightful review of Clostridioides difficile infection (CDI) in children. The authors highlight the increasing incidence of CDI in children, the unique challenges posed by this infection, and the need for improved diagnostic and treatment strategies. This study underscores the need for continued research to better understand and manage this challenging condition.
Date :
  1. Date Completed 2023-09-04
  2. Date Revised 2023-10-10
Further Info :

Pubmed ID

37560802

DOI: Digital Object Identifier

PMC10471512

Related Literature

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・Effects of fidaxomicin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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