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Zileuton ameliorates aminoglycoside and polymyxin-associated acute kidney injury in an animal model.

Author: EalesBrianna M, HudsonCole S, KajijiShama, LiuXinli, SmithJames E, TamVincent H, TruongLuan D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Aminoglycosides and polymyxins are antibiotics effective against multidrug-resistant Gram-negative bacteria, but they have dose-limiting nephrotoxicity. This study investigated whether zileuton can reduce nephrotoxicity associated with amikacin and polymyxin B in a rat model of acute kidney injury.
Paper Details　
Original Abstract of the Article :
Aminoglycosides and polymyxins are antibiotics with in vitro activity against MDR Gram-negative bacteria. However, their clinical use is hindered by dose-limiting nephrotoxicity. The objective of this project was to determine if zileuton can reduce nephrotoxicity associated with amikacin and polymyx...See full text at original site
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引用元：
https://doi.org/10.1093/jac/dkad246

データ提供：米国国立医学図書館（NLM）

Zileuton: A Potential Oasis in the Desert of Nephrotoxicity

[Nephrotoxicity] is a significant concern in the use of antibiotics like aminoglycosides and polymyxins. These drugs are our warriors in the fight against infections, but their side effects can be challenging. This study explores the potential of zileuton, a drug commonly used for asthma, as a potential solution to reduce kidney damage caused by these antibiotics. The researchers conducted experiments in a rat model of acute kidney injury to assess the protective effects of zileuton.

Hope on the Horizon for Kidney Protection

The results of this study suggest that zileuton may be a valuable ally in the battle against antibiotic-induced kidney injury. The study showed a reduction in nephrotoxicity when zileuton was used in combination with amikacin and polymyxin B. This finding opens up new avenues for exploring the potential of zileuton as a protective agent against antibiotic-related kidney damage.

Protecting Our Vital Oasis: The Kidneys

The kidneys are crucial organs, like oases in the desert, providing essential functions for our survival. This study highlights the importance of protecting these vital organs. While more research is needed, zileuton holds promise as a potential strategy for mitigating antibiotic-induced kidney injury. It's like carrying extra water in the desert to prevent dehydration.

Dr.Camel's Conclusion

The study presents a glimmer of hope for patients facing the risk of antibiotic-induced nephrotoxicity. Zileuton, a familiar drug in the fight against asthma, may hold the key to protecting our kidneys from the harmful effects of certain antibiotics.

Date :
  1. Date Completed 2023-10-04
  2. Date Revised 2023-10-11
Further Info :

Pubmed ID

37563789

DOI: Digital Object Identifier

10.1093/jac/dkad246

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SNS
PICO Info
in preparation
Languages

English

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