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Comparison of intravenously administered methadone, morphine and heroin.

Author: JasinskiD R, PrestonK L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Methadone was not more potent in producing euphoria relative to its other opiate-like effects in non-dependent post-addict volunteers. The study found that methadone produced a profile of effects that was indistinguishable from that of morphine and heroin.
Paper Details　
Original Abstract of the Article :
Data from previously reported studies suggest that methadone may be more euphorigenic than other morphine-like drugs. To determine whether methadone is more potent in producing euphoria relative to its other opiate-like effects, single doses of intravenously administered methadone, morphine, heroin ...See full text at original site
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引用元：
https://doi.org/10.1016/0376-8716(86)90079-7

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Methadone, Morphine, and Heroin: A Quest for Understanding

In the complex world of opioid analgesics, understanding the distinct effects of different medications is crucial for safe and effective treatment. This study compared the effects of intravenously administered methadone, morphine, and heroin in non-dependent post-addict volunteers. The researchers measured various physiological, subjective, and behavioral effects over a 24-hour period following drug administration. They found that methadone, morphine, and heroin produced indistinguishable profiles of effects, including euphoria, except for the duration of miosis (pupil constriction), which was longer lasting with methadone. This study challenges previous assumptions about methadone's purported selectivity for euphoria and suggests a more nuanced understanding of its effects.

A Balanced Perspective: Understanding Opioid Effects

The findings of this study highlight the complex nature of opioid effects and the importance of considering the nuances of individual drugs. It challenges the notion that methadone is uniquely euphorigenic and emphasizes the need for a balanced perspective in evaluating these medications. This research contributes to our understanding of opioid pharmacology and its implications for treatment strategies.

Navigating Opioid Treatment: A Multifaceted Approach

This research underscores the importance of a multifaceted approach to opioid treatment, considering the unique characteristics of each medication and the individual needs of patients. Healthcare providers must carefully assess patient history, current conditions, and treatment goals to determine the most appropriate opioid medication and dosage. Remember, informed decisions and personalized care are essential for navigating the complex world of opioid medications.

Dr. Camel's Conclusion

My dear friends, the desert of opioid treatment is a complex and challenging landscape, with each medication offering its own unique path. This study reminds us that what appears to be a shortcut can sometimes be a winding road, and that careful navigation is key. Remember to seek guidance from experienced travelers (your healthcare providers) and to choose the path that best suits your needs and circumstances. By understanding the subtleties of these medications, we can find our way through the desert and towards a place of healing and well-being.
Date :
  1. Date Completed 1986-10-30
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

3757766

DOI: Digital Object Identifier

10.1016/0376-8716(86)90079-7

Related Literature

Article Analysis
・Effects of methadone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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