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Population Pharmacokinetic Analysis Supports Initiation Treatment and Bridging from Sublingual Buprenorphine to Subcutaneous Administration of a Buprenorphine Depot (CAM2038) in the Treatment of Opioid Use Disorder.

Author: AcharyaChayan, BjörnssonMarcus, StrandgårdenKerstin, TibergFredrik

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This analysis compares the pharmacokinetics (PK) of buprenorphine (BPN) following intravenous, sublingual (SL), and subcutaneous (SC) administration of extended-release BPN depots (e.g., CAM2038) in the context of treating opioid use disorder (OUD). SC depots have shown advantages in providing more stable BPN levels, improving treatment outcomes, and reducing misuse risks compared to SL BPN.
Paper Details　
Original Abstract of the Article :
In treating opioid use disorder (OUD), subcutaneous (SC) extended-release buprenorphine (BPN) depots, e.g., CAM2038, have been shown to provide smaller and less frequent fluctuations in BPN plasma concentrations and pharmacodynamic responses, improve outcomes, reduce treatment burden, and lower risk...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520114/

データ提供：米国国立医学図書館（NLM）

Bridging Sublingual Buprenorphine to Subcutaneous Depot: A Pharmacokinetic Approach

Opioid use disorder (OUD) is a complex and challenging health issue. This research focuses on the pharmacokinetics of buprenorphine, a medication used to treat OUD, exploring the potential for a seamless transition from sublingual administration to a subcutaneous depot formulation (CAM2038). The study utilized a population pharmacokinetic analysis to understand the absorption, distribution, metabolism, and excretion of buprenorphine following different administration routes.

Subcutaneous Depot: A Potential Improvement in OUD Treatment

The research suggests that subcutaneous depot formulations, such as CAM2038, could provide a more stable and consistent buprenorphine plasma concentration, potentially leading to improved outcomes and reduced treatment burden. It's like finding a steady stream of water in a dry desert - a reliable source of hydration and support. The study highlights the potential advantages of subcutaneous depot formulations, including reduced risks of misuse and diversion compared to daily sublingual administration.

Towards More Effective OUD Treatment

This research offers a promising avenue for improving the management of opioid use disorder. By understanding the pharmacokinetic properties of buprenorphine, researchers can develop more effective and patient-centered treatment strategies. The study underscores the need for continued research and development of innovative treatment approaches for OUD.

Dr.Camel's Conclusion

This research points toward a more efficient and effective approach to treating opioid use disorder, a challenging health issue affecting many individuals. It's a reminder that like the desert, where change is often gradual but impactful, advancements in medicine can lead to significant improvements in treatment outcomes. The study highlights the potential of subcutaneous depot formulations, potentially leading to a future where OUD treatment is more stable, manageable, and personalized.

Date :
  1. Date Completed 2023-09-26
  2. Date Revised 2023-10-05
Further Info :

Pubmed ID

37584841

DOI: Digital Object Identifier

PMC10520114

SNS
PICO Info
in preparation
Languages

English

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