Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review.

Author: BrandRomana, CastroJanine R, HuynhKatherine, Killam-WorrallLisa, LindleyBryn, PatelDipa S, TorresBrittany Palasik

Paper Details 
Original Abstract of the Article :
OBJECTIVE: This review highlights adverse effects of baclofen and tizanidine in older community-dwelling adults. DATA SOURCES: A literature search was conducted, including search terms of "adverse effect," "baclofen," "elderly," "falls," "fractures," and "tizanidine." Studies were included if they ...See full text at original site
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引用元:
https://doi.org/10.1177/10600280231193080

データ提供:米国国立医学図書館(NLM)

Navigating the Side Effects of Muscle Relaxants in Older Adults

Muscle relaxants are a common treatment for muscle spasms and pain, but their use in older adults can present unique challenges. This systematic review explores the potential adverse effects of baclofen and tizanidine, two commonly used muscle relaxants, in older adults living in the community. The researchers reviewed existing literature and analyzed data from the FDA Adverse Event Reporting System (FAERS). Their findings suggest that both baclofen and tizanidine can be associated with concerning side effects in older adults, including falls, fractures, and cognitive impairment. These findings underscore the importance of careful monitoring and dose adjustments in older adults to minimize these potential risks.

A Cautious Approach: Understanding the Risks of Muscle Relaxants in Older Adults

This review highlights the potential risks associated with baclofen and tizanidine in older adults. The findings suggest that these drugs can increase the risk of falls and fractures, highlighting the importance of cautious use and close monitoring in this population. The review found a 27.8% and 29.2% incidence of falls for baclofen and tizanidine respectively, emphasizing the importance of fall prevention strategies and careful assessment of fall risk factors. This is like navigating a treacherous desert path, where careful steps and a keen eye for potential hazards are crucial for safe passage.

Balancing Benefits and Risks: A Personalized Approach to Muscle Relaxant Therapy

This review emphasizes the importance of a personalized approach to muscle relaxant therapy in older adults. While these drugs can provide relief from muscle spasms and pain, the potential risks must be carefully considered. Healthcare providers should initiate treatment with lower doses and gradually increase as needed, closely monitoring for any adverse effects. This approach is like carefully selecting a camel for a long desert journey, ensuring its strength and resilience are suitable for the challenges ahead.

Dr.Camel's Conclusion

This review serves as a reminder that even seemingly simple medications can have complex effects, especially in vulnerable populations like older adults. The careful consideration of potential risks and benefits is paramount when prescribing muscle relaxants to older adults. It's like traversing a vast and unforgiving desert, where every step requires careful planning and awareness of potential hazards. By understanding the nuances of these medications and tailoring treatment plans to individual needs, we can ensure a smoother and safer journey through this challenging terrain.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-17
Further Info :

Pubmed ID

37589096

DOI: Digital Object Identifier

10.1177/10600280231193080

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