Efficient biosynthesis of Vibegron intermediate using a novel carbonyl reductase based on molecular modification of hydrogen bonding network regulation.

Author: ChenKai-Li, FangWei-Mei, LiuZhi-Qiang, YangFei, ZhangXiao-Jian, ZhengYu-Guo

Paper Details 
Original Abstract of the Article :
Vibegron is a novel, potent, highly selective &#946;<sub>3</sub>-adrenergic receptor agonist for the treatment of overactive bladder with higher therapeutic capacity and lower side effects. Methyl(2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate ((2S,3R)-aminohydroxy ester) is a ke...See full text at original site
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引用元:
https://doi.org/10.1016/j.bioorg.2023.106788

データ提供:米国国立医学図書館(NLM)

The Restless Legs Syndrome Desert: Exploring the Effects of Exercise

Restless legs syndrome (RLS) is a common sleep disorder that can leave individuals feeling restless and unable to sleep. Like a lost traveler in the vast desert, individuals with RLS often seek relief from their symptoms. This study delved into the perceptions of exercise as a potential solution for RLS, exploring the experiences and perspectives of individuals living with this condition.

Exercise and Restless Legs Syndrome: A Journey to Relief

The results of this study showed that a majority of participants reported positive experiences with exercise, noting improvement in their RLS symptoms. This suggests that exercise can be a valuable tool for managing RLS. However, the study also highlighted that exercise should be approached with caution, as abrupt changes in exercise routine could potentially trigger RLS symptoms.

Navigating the Desert of RLS: Exercise Strategies for Relief

This study provides valuable insights for individuals living with RLS, suggesting that consistent exercise may be beneficial. It's important to find a consistent exercise routine that works best for you, considering your individual needs and preferences. For some, morning exercise might be more beneficial, while others may find evening exercise more effective. Remember to start slowly and gradually increase the intensity and duration of your workouts.

Dr. Camel's Conclusion

This study underscores the importance of exploring exercise as a potential tool for managing RLS. While the desert of RLS can be challenging, it's encouraging to know that exercise could offer a path to relief. Individuals should consult with their healthcare providers to develop a personalized exercise plan that meets their specific needs and helps them navigate the journey to better sleep and overall well-being.

Date :
  1. Date Completed 2023-09-18
  2. Date Revised 2023-09-18
Further Info :

Pubmed ID

37598433

DOI: Digital Object Identifier

10.1016/j.bioorg.2023.106788

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Languages

English

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