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Childhood-onset systemic lupus erythematosus: characteristics and the prospect of glucocorticoid pulse therapy.

Author: GuoLishuang, LiuCongcong, LiuJinxiang, PanLu, PunaroMarilynn, YangSirui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

GC pulse therapy is a promising treatment for childhood-onset systemic lupus erythematosus (cSLE) as it can achieve disease remission quickly and reduce side effects associated with high-dose oral glucocorticoid (GC) therapy, such as weight gain, osteoporosis, and mood swings. Studies suggest that GC pulse therapy can achieve disease remission with a reduction in oral prednisone doses.
Paper Details　
Original Abstract of the Article :
Childhood-onset systemic lupus erythematosus (cSLE) is an autoimmune disease that results in significant damage and often needs more aggressive treatment. Compared to adult-onset SLE, cSLE has a stronger genetic background and more prevalent elevated type I Interferon expression. The management of c...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448525/

データ提供：米国国立医学図書館（NLM）

Childhood-Onset Systemic Lupus Erythematosus (cSLE): A Complex Autoimmune Disorder

In the realm of autoimmune diseases, childhood-onset systemic lupus erythematosus (cSLE) is a complex and challenging condition, like a vast and unforgiving desert. This review delves into the unique characteristics, pathogenesis, and manifestations of cSLE, highlighting the need for more aggressive treatment approaches in this population. The review also explores the potential benefits of glucocorticoid pulse therapy, a promising strategy for achieving rapid disease remission and minimizing the side effects of long-term glucocorticoid treatment.

The Challenge of Managing cSLE

This review underscores the significant challenges of managing cSLE in children, emphasizing the importance of individualized treatment plans that consider the unique needs and developmental stages of this population. It's like navigating a challenging desert landscape, carefully selecting the right path and resources to ensure a safe and successful journey for young travelers.

Hope for a Brighter Future

This review offers hope for individuals with cSLE, particularly children, by exploring the potential benefits of glucocorticoid pulse therapy. This approach could provide a more effective and less toxic treatment option, potentially improving the quality of life and long-term outcomes for young patients. It's like finding a hidden oasis in the heart of a desert, offering relief and rejuvenation for those affected by this challenging condition.

Dr.Camel's Conclusion

This review delves into the intricate world of cSLE, reminding us that even the most challenging medical conditions can be addressed with ongoing research and innovative treatment approaches. By understanding the unique characteristics of cSLE in children and exploring new therapeutic strategies like glucocorticoid pulse therapy, we can work towards a brighter future for those affected by this complex autoimmune disorder. It's like embarking on a journey through a desert landscape, seeking to discover new paths and resources to improve the lives of those in need.

Date :
  1. Date Completed 2023-08-29
  2. Date Revised 2023-08-31
Further Info :

Pubmed ID

37638017

DOI: Digital Object Identifier

PMC10448525

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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