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Effects of diet and gender on the pharmacokinetics of oral lenvatinib: A clinical trial in healthy Chinese participants.

Author: HeKun, MuHongli, WeiYilin, WenQing, YuYuan, ZhangWenyu, ZhangXiaoran

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Lenvatinib can be administered under fasted or fed conditions without significant impact on its clinical efficacy. This study investigating the pharmacokinetic profile of lenvatinib found that a high-fat diet did alter the pharmacokinetic parameters but not to a clinically significant degree. Therefore, lenvatinib remains suitable for administration with or without food.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Lenvatinib is a tyrosine kinase inhibitor that helps prevent angiogenesis. In this study, we investigated the potential influencing factors on lenvatinib pharmacokinetics to provide a reference for clinical application. MATERIALS AND METHODS: All healthy participants received a single do...See full text at original site
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引用元：
https://doi.org/10.5414/CP204440

データ提供：米国国立医学図書館（NLM）

The Influence of Diet and Gender on Lenvatinib Pharmacokinetics

Lenvatinib, a tyrosine kinase inhibitor used to prevent angiogenesis, is a powerful tool in the fight against cancer. However, like a camel traversing a desert, the journey of a drug through the body can be influenced by various factors, including diet and gender.

This study aimed to investigate the impact of these factors on lenvatinib pharmacokinetics, providing valuable insights for optimizing treatment strategies.

Exploring the Pharmacokinetic Landscape

Healthy participants received a single dose of lenvatinib with a high-fat meal or in a fasted state. The researchers meticulously measured lenvatinib plasma concentrations, revealing the impact of a high-fat diet on its pharmacokinetic profile. While the high-fat diet did alter the pharmacokinetic parameters, the study concluded that the changes were not significant enough to affect the drug's clinical efficacy.

Navigating the Desert of Pharmacokinetics

This study provides valuable information for clinicians. It suggests that lenvatinib can be administered under both fasted and fed conditions, offering flexibility in treatment schedules.

Dr. Camel's Conclusion

This study is a reminder that the journey of a drug through the body is a complex dance influenced by various factors. By understanding the influence of diet and gender on lenvatinib pharmacokinetics, we can navigate this intricate desert and optimize treatment strategies for our patients.

Date :
  1. Date Completed 2023-10-23
  2. Date Revised 2023-10-23
Further Info :

Pubmed ID

37644876

DOI: Digital Object Identifier

10.5414/CP204440

Related Literature

Article Analysis
・Effects of lenvatinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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