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Protective Effect of Quercetin and p-Coumaric Acid (p-CA) Against Cardiotoxicity: An <i>In Silico</i> Study.
Author: BhadanaRenu, RaniVibha
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Hydroxychloroquine (HCQ) is a common antimalarial drug that has been used effectively in the treatment of various rheumatic and auto-immunity diseases. The major side effects and drawbacks associated with HCQ are cardiotoxicity, retinopathy, gastrointestin...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.2174/2772574X14666230831100901
データ提供:米国国立医学図書館(NLM)
Quercetin and p-Coumaric Acid: A Natural Defense Against Hydroxychloroquine Cardiotoxicity
Hydroxychloroquine (HCQ) is a valuable drug used to treat various conditions, but like a desert oasis that can also harbor hidden dangers, it can have side effects. This study explores the potential of two natural compounds, quercetin and p-coumaric acid, to mitigate the cardiotoxicity associated with HCQ. It's like seeking a natural solution to counter the potential adverse effects of a powerful medicine, creating a safer and more balanced approach to treatment.
A Natural Shield Against Cardiotoxicity
The study uses in silico modeling to investigate the potential therapeutic effects of quercetin and p-coumaric acid against HCQ-induced cardiotoxicity. It's like building a virtual model to understand the complex interactions of these compounds, seeking to find a way to protect the heart from harm. The research identifies specific targets and pathways involved in HCQ-induced cardiotoxicity, providing insights into how these natural compounds might mitigate the adverse effects. It's like mapping out the terrain of cardiotoxicity, understanding the mechanisms by which these compounds can protect the heart.
A Promising Path Towards Safer Treatments
This research, like a journey through the desert of drug discovery, offers a glimpse into the potential of natural compounds to enhance the safety of existing medications. It's a reminder that even in the face of challenging side effects, there are often natural solutions to be found. The study encourages further investigation into the therapeutic potential of these compounds, offering a path towards safer and more effective treatment options.
Dr. Camel's Conclusion
This study, like a camel caravan seeking a safe passage through the desert of drug development, explores the potential of natural compounds to mitigate the cardiotoxicity associated with HCQ. It's a reminder that nature often holds the key to solutions, offering a path towards safer and more effective treatment options.
Date :
- Date Completed 2023-11-27
- Date Revised 2023-11-27
Further Info :
Related Literature
English
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