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Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes.

Author: FederAnna-Lena, KreitmeierKlaus-Georg, MaierLars S, SagCan Martin, StengelLaura, TarnowskiDaniel, TrumMaximilian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Inhibition of Bruton tyrosine kinase (BTK) by Ibrutinib impairs insulin-like growth factor 1 (IGF-1)-dependent activation of intracellular Ca handling in adult ventricular mouse myocytes in the face of disrupted Akt signaling and absent SERCA2a upregulation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The Bruton tyrosine kinase (BTK) inhibitor Ibrutinib is associated with a higher incidence of cardiotoxic side effects including heart failure (HF). OBJECTIVES: Ibrutinib is capable of inhibiting PI3K/Akt signaling in neonatal rat ventricular cardiomyocytes when stimulated with insulin-...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466040/

データ提供：米国国立医学図書館（NLM）

Ibrutinib's Impact on Intracellular Calcium Handling in Heart Cells

Ibrutinib, a medication used to treat certain types of [cancer], has been linked to [cardiotoxicity], including [heart failure]. This study investigated how ibrutinib affects the [intracellular calcium handling] of heart cells, specifically focusing on the role of [insulin-like growth factor 1 (IGF-1)]. The researchers exposed isolated mouse heart cells to IGF-1 with or without ibrutinib and measured changes in intracellular calcium levels. Their findings demonstrate that ibrutinib impairs IGF-1-dependent activation of intracellular calcium handling in heart cells, potentially contributing to its cardiotoxic effects.

Ibrutinib's Potential for Disrupting Heart Cell Function

The study found that ibrutinib significantly impairs IGF-1-mediated activation of intracellular calcium handling in heart cells. This disruption could contribute to the cardiotoxic effects associated with ibrutinib. Further research is needed to understand the precise mechanisms and clinical implications of these findings.

Navigating the Risks and Benefits of Ibrutinib

This study underscores the importance of understanding the potential side effects of cancer treatments, especially those that might impact heart health. While ibrutinib can be a valuable treatment option for some cancers, it is crucial for healthcare providers to carefully monitor patients for signs of cardiotoxicity and manage potential risks.

Dr.Camel's Conclusion

The heart, like a desert oasis, is essential for our survival. This study highlights the potential impact of ibrutinib on heart cell function. While it can be a powerful weapon against certain cancers, ibrutinib might also disrupt the delicate balance of calcium within heart cells, potentially leading to problems like heart failure. It's a reminder that even in the fight against disease, we must always be mindful of the collateral damage.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-02
Further Info :

Pubmed ID

37655217

DOI: Digital Object Identifier

PMC10466040

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Languages

English

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