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Partial Reversal of Anosmia Following Platinum-Based Chemotherapy in a Patient With Colorectal Adenocarcinoma.

Author: AziziArmon, BhandarkarNaveen, DayyaniFarshid, MahadevanAditya

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

While platinum-based chemotherapy typically worsens taste and smell, this case report documents an individual regaining their sense of smell following treatment with oxaliplatin for colorectal adenocarcinoma. The improvement is hypothesized to be due to oxaliplatin-induced destruction of nasal polyps. While chemotherapy-induced taste and smell changes can negatively impact quality of life, this case suggests potential therapeutic benefits for patients with anosmia secondary to nasal polyposis.
Paper Details　
Original Abstract of the Article :
Platinum-based chemotherapy is known to cause taste and smell changes (TSCs) via a host of mechanisms, including altered receptor activity, saliva/mucus production, and induction of receptor destruction via mitotic inhibition. In the literature to date, these changes have primarily resulted in worse...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479930/

データ提供：米国国立医学図書館（NLM）

Partial Reversal of Anosmia Following Platinum-Based Chemotherapy in a Patient With Colorectal Adenocarcinoma

This case report explores an unusual and potentially beneficial side effect of platinum-based chemotherapy in a patient with colorectal adenocarcinoma. Imagine a desert landscape where a sudden rain shower brings life to previously parched land – this is what the authors observed in this patient, who experienced a partial reversal of anosmia, a loss of smell, after receiving chemotherapy.

A Serendipitous Discovery

The case report describes a surprising observation – a patient experiencing a partial recovery of olfactory function after receiving platinum-based chemotherapy. This unexpected finding is like a hidden oasis in a desert, revealing a potential therapeutic benefit of this commonly used treatment. The authors theorize that the chemotherapy may have targeted and destroyed nasal polyps, which were previously responsible for the patient's anosmia. This intriguing observation calls for further investigation to explore the potential for platinum-based chemotherapy to alleviate anosmia caused by nasal polyps.

A Promising Path

This case report opens a door to new possibilities in the treatment of anosmia, suggesting that platinum-based chemotherapy may offer a potential solution for some patients experiencing olfactory dysfunction. It's like discovering a new route through a previously unexplored desert landscape, offering hope for those struggling with this debilitating condition. The authors' findings encourage further research to validate this intriguing observation and explore its clinical applications.

Dr. Camel's Conclusion

This case report highlights a potentially unexpected and beneficial side effect of platinum-based chemotherapy in a patient with colorectal adenocarcinoma, suggesting a possible therapeutic application for anosmia caused by nasal polyps. This intriguing discovery, like finding a hidden oasis in a vast desert, offers hope for those struggling with this debilitating condition and encourages further research to explore its potential clinical applications.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-08
Further Info :

Pubmed ID

37674764

DOI: Digital Object Identifier

PMC10479930

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Article Analysis
・Effective treatment of taste and smell disorders
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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