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Secular Trends in Central Nervous System-Active Polypharmacy Among Serial Cross-Sections of US Adults, 2009-2020.

Author: BurkeJames F, GerlachLauren B, GrowdonMatthew E, NiznikJoshua D, TermanSamuel W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study characterized trends in central nervous system (CNS)-active polypharmacy in US adults from 2009 to 2020. The prevalence of CNS-active polypharmacy increased from 2.1% to 2.6%, while the prevalence of any CNS-active medication increased from 21.0% to 24.6%. Gabapentin was the most common CNS-active medication, and its prevalence increased significantly in older adults.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Data comprehensively examining trends in central nervous system (CNS)-active polypharmacy are limited. The objective of this cross-sectional study was to characterize the composition of and trends in CNS-active medication use in US adults. METHODS: We included all participants ≥ 18 year...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37695395

データ提供：米国国立医学図書館（NLM）

The Growing Trend of CNS-Active Polypharmacy in US Adults

Our brains, the command centers of our bodies, are complex and intricate. Central Nervous System (CNS)-active medications are often prescribed to address a wide range of neurological and psychiatric conditions. Polypharmacy, the use of multiple medications, can be a double-edged sword. This study examines the prevalence of CNS-active polypharmacy in US adults and explores the trends in medication use from 2009 to 2020, focusing on the potential consequences of this growing trend.

A Rising Tide of Polypharmacy

The study revealed that the prevalence of CNS-active polypharmacy has steadily increased in the US, particularly among older adults. The use of antiepileptics, specifically gabapentin, has risen significantly, raising concerns about potential adverse effects and interactions. This increase in polypharmacy raises questions about appropriate prescribing practices and the need for careful monitoring of patients receiving multiple CNS-active medications.

Navigating the Risks and Benefits

The study highlights the need for cautious prescribing of CNS-active medications, particularly in older adults. Like a desert traveler, navigating through a maze of dunes, physicians must carefully consider the potential risks and benefits of polypharmacy and strive to optimize medication regimens to ensure patient safety and efficacy. Regular monitoring and communication between patients and healthcare professionals are essential for safe and effective medication management.

Dr. Camel's Conclusion

This study offers a sobering reminder of the growing trend of CNS-active polypharmacy in the US. It emphasizes the importance of responsible prescribing and the need for close monitoring of patients receiving multiple medications. As the desert landscape of polypharmacy becomes more complex, careful navigation and vigilance are essential to ensure patient well-being.

Date :
  1. Date Completed 2023-09-25
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

37695395

DOI: Digital Object Identifier

NIHMS1938240

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Languages

English

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