Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart.

Author: BatoolSaima, ChaudhryAhtshamullah, FatimaGhulam, NoorJawad, NoorRiwad

Paper Details 
Original Abstract of the Article :
To keep inflammatory bowel disease (IBD) in remission, mesalamine is frequently utilized. It primarily targets the inflammatory response and lowers prostaglandin and leukotriene synthesis. It can be applied topically, orally, or as a suppository. It is typically well tolerated, but occasionally it c...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503225/

データ提供:米国国立医学図書館(NLM)

Mesalamine: A Double-Edged Sword in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), a chronic condition that affects the digestive system, requires careful management to control inflammation and prevent complications. Mesalamine, a medication commonly used to treat IBD, targets the inflammatory response and is generally well-tolerated. However, this research highlights the potential for serious side effects associated with mesalamine, particularly affecting the lungs and heart.

The study describes two cases of severe mesalamine-induced toxicity, one resulting in cardiomyopathy (heart muscle disease) and the other in pneumonitis (lung inflammation). These cases underscore the importance of monitoring patients closely for any signs of adverse effects, particularly those involving the heart and lungs.

While mesalamine remains a valuable treatment for IBD, this research serves as a reminder that even seemingly safe medications can have unexpected side effects. Early detection and treatment of these side effects are crucial for preventing serious complications and ensuring the best possible outcomes for patients.

Navigating the Desert of Side Effects

This research, like a camel navigating a vast desert landscape, reveals the importance of vigilance in managing IBD and other chronic conditions. The study highlights the potential for serious side effects, even with commonly used medications like mesalamine. This underscores the need for close monitoring and prompt intervention to prevent serious complications.

A Balancing Act in IBD Management

Mesalamine, like a double-edged sword, offers significant benefits in managing IBD but can also pose risks. This research emphasizes the need for careful monitoring and a balanced approach to ensure that the benefits outweigh the potential risks, maximizing patient safety and well-being.

Dr.Camel's Conclusion

This research, like a camel traversing a desert landscape, reminds us that even seemingly safe medications can have unexpected consequences. While mesalamine is a valuable tool in managing IBD, it's important to remain vigilant for potential side effects, especially those affecting the heart and lungs. Early detection and treatment are essential for navigating the complexities of IBD management and ensuring the best possible outcomes for patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-19
Further Info :

Pubmed ID

37719567

DOI: Digital Object Identifier

PMC10503225

SNS
PICO Info
in preparation
Languages

English

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