Effects of elexacaftor/tezacaftor/ivacaftor on liver fibrosis markers in adults with cystic fibrosis.

Author: AthwalVarinder, BarryPeter J, Bright-ThomasRowland J, HanleyKaren Piper, JonesAndrew M, ScottJennifer, TewkesburyDaniel H

Paper Details 
Original Abstract of the Article :
BACKGROUND: There are limited studies to date on the effects of elexacaftor/tezacaftor/ivacaftor (E/T/I) on markers of liver fibrosis in adults with cystic fibrosis (CF). This study aims to analyse changes in makers of liver fibrosis before and after initiation of E/T/I in CF adults. METHODS: Outco...See full text at original site
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引用元:
https://doi.org/10.1016/j.jcf.2023.09.006

データ提供:米国国立医学図書館(NLM)

Elexacaftor/Tezacaftor/Ivacaftor: A New Oasis for Cystic Fibrosis?

The fight against cystic fibrosis (CF), a debilitating genetic disease, is a constant battle in the field of [Pulmonary Medicine]. This research, like a dedicated researcher searching for a cure, explores the potential impact of elexacaftor/tezacaftor/ivacaftor (E/T/I) on liver fibrosis markers in adults with CF. The authors, like skilled navigators charting a new course, analyze changes in liver fibrosis markers before and after the initiation of E/T/I. The study, like a carefully curated map, reveals that while E/T/I does not appear to significantly alter liver fibrosis markers overall, it may offer a potential benefit for individuals with severe liver disease.

A Potential Shift in the Landscape

This research suggests that E/T/I might offer a potential treatment benefit for individuals with severe CF-related liver disease. The study's findings, like a glimmer of hope in the desert, indicate that E/T/I may have a positive impact on liver fibrosis in this specific patient population.

A New Path for CF Treatment

This research offers a glimpse into the evolving landscape of CF treatment. E/T/I, a novel triple-combination therapy, appears to have potential benefits for managing liver fibrosis in individuals with severe CF-related liver disease.

Dr. Camel's Conclusion

This research is like a beacon of hope in the desert of cystic fibrosis. The findings suggest that E/T/I, a novel triple-combination therapy, may offer a potential treatment benefit for individuals with severe CF-related liver disease. The study underscores the ongoing quest to find effective treatments for this challenging disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-21
Further Info :

Pubmed ID

37735009

DOI: Digital Object Identifier

10.1016/j.jcf.2023.09.006

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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