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Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes.
Author: CooperBlake L, PosnackNikki Gillum, SalamehShatha
Original Abstract of the Article :
BACKGROUND: Bisphenol A (BPA) is commonly used to manufacture consumer and medical-grade plastics. Due to health concerns, BPA substitutes are being incorporated - including bisphenol S (BPS) and bisphenol F (BPF) - without a comprehensive understanding of their toxicological profile. OBJECTIVE: Pr...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515916/
データ提供：米国国立医学図書館（NLM）
Comparative Cardiotoxicity Assessment of Bisphenol Chemicals and Estradiol Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Bisphenol A (BPA) and its substitutes, bisphenol S (BPS) and bisphenol F (BPF), are ubiquitous chemicals found in many everyday products. Concerns have been raised about their potential cardiotoxicity. This study investigates the effects of BPA, BPS, BPF, and estradiol (E2) on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The researchers used microelectrode array (MEA) technology and live-cell fluorescent imaging to assess cardiac function in response to chemical exposure.
Exploring the Cardiotoxic Potential of Bisphenol Chemicals
The study found that BPA, BPF, and E2, at micromolar concentrations, disrupted cardiac function, leading to decreased contractility and altered electrical activity. BPS, however, had minimal effects on hiPSC-CM function. The findings suggest that BPA and its substitutes may pose cardiotoxic risks, particularly at higher concentrations.
Bisphenol Chemicals and the Heart: A Camel's Perspective
Imagine a camel's heart, strong and resilient, adapting to the harsh desert environment. This study examines the potential impact of bisphenol chemicals on the delicate balance of cardiac function. Like a desert oasis, the human heart requires a carefully regulated environment to thrive. This research is a reminder that even seemingly small exposures to environmental chemicals can have a significant impact on our health.
Dr.Camel's Conclusion
This research provides valuable insights into the potential cardiotoxicity of BPA and its substitutes. It highlights the importance of further research to understand the long-term effects of these chemicals on human health. Like a camel seeking a safe and sustainable water source, we must remain vigilant in our efforts to protect ourselves from environmental toxins.
Date :
- Date Completed n.d.
- Date Revised 2023-11-20
Further Info :
Related Literature
English
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