Liver injury in children: signal analysis of suspected drugs based on the food and drug administration adverse event reporting system.

Author: ChengGuo, HuangLiang, JiaZhijun, JiaoXuefeng, LiHailong, LiuYan, WanChaomin, WangHuiqing, ZengLinan, ZhangLei, ZhangLingli, ZhangWei

Paper Details 
Original Abstract of the Article :
BACKGROUND: Evidence of drug-induced liver injury is abundant in adults but is lacking in children. Our aim was to identify suspected drug signals associated with pediatric liver injury. METHODS: Hepatic adverse events (HAEs) among children reported in the Food and Drug Administration Adverse Event...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537493/

データ提供:米国国立医学図書館(NLM)

Identifying Suspected Drug Signals Associated with Pediatric Liver Injury

Drug-induced liver injury is a serious concern, especially in children. Imagine a child playing in a desert, where each drug is a different flower. Some flowers might be harmless, while others could contain toxins. This study delves into the vast database of the Food and Drug Administration Adverse Event Reporting System, like a map of the desert, to identify suspected drug signals associated with pediatric liver injury. The researchers analyzed reports of hepatic adverse events in children, looking for patterns and trends. They found that certain drugs, like paracetamol, methotrexate, and valproic acid, were more frequently linked to liver injury. The study also identified six new potential drug signals, emphasizing the need for further investigation.

Understanding Drug Safety in Children: New Insights into Pediatric Liver Injury

This study reveals the importance of understanding the potential risks of drugs, especially in children. It's like carefully examining each flower in the desert to ensure it's safe for a child to touch. The findings highlight the need for ongoing monitoring and research to identify drug signals associated with pediatric liver injury, helping to protect children from potential harm.

Dr. Camel's Conclusion

This research emphasizes the importance of vigilance when it comes to drug safety, particularly in children. The study's findings, like precious desert maps, guide us towards safer drug use and emphasize the need for continued research to protect the health of our youngest explorers.

Date :
  1. Date Completed 2023-10-04
  2. Date Revised 2023-11-23
Further Info :

Pubmed ID

37770847

DOI: Digital Object Identifier

PMC10537493

SNS
PICO Info
in preparation
Languages

English

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