Antipsychotic dose reduction and discontinuation versus maintenance treatment in people with schizophrenia and other recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial.

Author: BarnesThomas, CooperRuth, CrellinNadia, DartonKatherine, FreemantleNick, HorneRobert, HorowitzMark, HunterRachael, JhaMithilesh, JohnsonSonia, KentLyn, LewisGlyn, LongMaria, MarstonLouise, MoncrieffJoanna, MorantNicola, PinfoldVanessa, PriebeStefan, SmithRuth, StansfeldJacki, VickerstaffVictoria

Paper Details 
Original Abstract of the Article :
Maintenance antipsychotic medication is recommended for people with schizophrenia or recurrent psychosis, but the adverse effects are burdensome, and evidence on long-term outcomes is sparse. We aimed to assess the benefits and harms of a gradual process of antipsychotic reduction compared with main...See full text at original site
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引用元:
https://doi.org/10.1016/S2215-0366(23)00258-4

データ提供:米国国立医学図書館(NLM)

Antipsychotic Dose Reduction: A Balancing Act for Schizophrenia

Maintenance antipsychotic medication is a cornerstone of treatment for schizophrenia and recurrent psychotic disorders. This study investigates the potential benefits and risks of a gradual process of antipsychotic dose reduction compared to maintenance treatment. The RADAR trial, an open, parallel-group, randomized controlled trial, aimed to assess the long-term outcomes of dose reduction versus maintenance therapy.

The study hypothesized that antipsychotic dose reduction could improve social functioning, while potentially increasing the risk of relapse in the short term. The trial will provide valuable data on the long-term outcomes of antipsychotic dose reduction, helping clinicians make informed decisions about medication management for individuals with schizophrenia and other recurrent psychotic disorders.

Navigating the Complexities of Antipsychotic Treatment

This research provides valuable insights into the long-term effects of antipsychotic medication management, offering data-driven guidance for clinicians. By understanding the potential benefits and risks of dose reduction versus maintenance therapy, clinicians can tailor treatment strategies to individual patient needs and preferences, aiming to improve both clinical outcomes and quality of life.

Schizophrenia: Finding the Right Balance

Imagine schizophrenia as a complex desert landscape, with unpredictable shifts in the sand dunes. Antipsychotic medication, like a sturdy camel, can provide stability and support. This study explores the delicate balance of antipsychotic dose reduction, seeking to optimize treatment while minimizing risks. The researchers are like experienced desert guides, carefully navigating the terrain to find the most effective path for individuals with schizophrenia.

Dr.Camel's Conclusion

Schizophrenia, like a vast and shifting desert, can be a challenging landscape to navigate. This study explores the potential benefits and risks of antipsychotic dose reduction, providing valuable insights for clinicians seeking to find the right balance for each individual. The research team, like skilled desert guides, are dedicated to finding the most effective and safe path for individuals with schizophrenia, ensuring their well-being and improving their quality of life.

Date :
  1. Date Completed 2023-11-01
  2. Date Revised 2023-11-01
Further Info :

Pubmed ID

37778356

DOI: Digital Object Identifier

10.1016/S2215-0366(23)00258-4

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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