Indication for a Pneumocystis Prophylaxis Therapy in Patients with Vascular Anomalies Treated with PIK3/AKT/mTOR Pathway Inhibitors: Experts' Opinion and Systematic Review from the Literature.

Author: Allemang-TrivalleAude, EdéeAfi-Emiliène, GiraudeauBruno, HarchaouiEmilie, Jonville-BeraAnnie-Pierre, LeducqSophie, MaruaniAnnabel, MaurierAnaïs, NavarroMaxime, ZejliTarik

Paper Details 
Original Abstract of the Article :
Vascular anomalies (VAs) are increasingly being treated with PI3K/AKT/mTOR pathway inhibitors. These drugs have immunosuppressive properties and thus theoretically overexpose patients to opportunistic infections, especially Pneumocystis jirovecii pneumonia (PJP). PJP prophylaxis use lacks consensus....See full text at original site
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引用元:
https://doi.org/10.1159/000533675

データ提供:米国国立医学図書館(NLM)

PIK3/AKT/mTOR Pathway Inhibitors and the Risk of Pneumocystis Pneumonia in Patients with Vascular Anomalies

This study explores the potential risks associated with [treatment method] used for vascular anomalies (VAs). It's a journey into the desert of [research field], where we seek to understand the potential complications of these powerful drugs. The authors review the literature and provide expert opinion regarding the use of pneumocystis prophylaxis in patients receiving [treatment method]. Their findings suggest that while there is a theoretical risk of Pneumocystis jirovecii pneumonia (PJP) in these patients, the prevalence of PJP remains unclear. The study calls for further investigation to determine the optimal approach to PJP prophylaxis in this specific population.

The Need for Further Investigation into PJP Prophylaxis

The study highlights the importance of personalized medicine, where treatment decisions are tailored to individual patient needs and risks. While the theoretical risk of PJP exists, more research is needed to clarify the true prevalence and determine the appropriate course of action for prophylaxis. This emphasizes the dynamic nature of medical knowledge and the need for continuous research to refine best practices and optimize patient care.

Navigating the Desert of VA Treatment

The study provides a valuable reminder that the use of powerful medications like [treatment method] comes with potential risks. It highlights the importance of careful patient monitoring, early detection of potential complications, and the need for ongoing research to refine treatment strategies. This study encourages a collaborative approach between clinicians and researchers to ensure the best possible care for patients with VAs.

Dr.Camel's Conclusion

This study emphasizes the importance of careful consideration and personalized care when treating patients with VA. While [treatment method] offers a promising treatment option, we must remain vigilant about potential complications like PJP. The journey through the desert of VA treatment requires a collaborative effort between clinicians and researchers to ensure the best possible outcomes for our patients.

Date :
  1. Date Completed 2023-12-07
  2. Date Revised 2023-12-07
Further Info :

Pubmed ID

37793356

DOI: Digital Object Identifier

10.1159/000533675

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Languages

English

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