Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model.

Author: ImJeonghyeon, JinBae Suk, KimHwan Hee, KimIn Kyoung, KimSei Won, LeeHeayon, LeeSang Haak, YeoChang Dong

Paper Details 
Original Abstract of the Article :
Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this study, we evaluated the effects of IH in an older mouse model of bleomycin-induced...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636542/

データ提供:米国国立医学図書館(NLM)

Aging and Intermittent Hypoxia: A Double Whammy for Lung Health

This study investigates the impact of aging and intermittent hypoxia (IH) on lung health, using a bleomycin-induced pulmonary fibrosis mouse model. The study focuses on older mice, simulating the prevalence of obstructive sleep apnea (OSA) in older patients with idiopathic pulmonary fibrosis (IPF). The study found that IH exacerbated lung fibrosis in older mice, highlighting the potential dangers of OSA in this population. The study emphasizes the need for early diagnosis and treatment of OSA in older patients with IPF to prevent further lung damage.

Aging and Sleep Disorders: A Complex Interplay

This research highlights the complex interplay between aging, sleep disorders, and lung health. The study's findings underscore the importance of addressing sleep disorders like OSA in older individuals, particularly those with IPF, to mitigate the risk of further lung damage. This research is like mapping a desert landscape, where age and sleep disorders are like shifting sands, influencing the overall health and well-being of the inhabitants.

Protecting Lung Health as We Age

This research underscores the need for vigilance in maintaining lung health as we age, particularly when it comes to sleep disorders like OSA. Early diagnosis and treatment of OSA, particularly in individuals with IPF, can be crucial for preventing further lung damage. This research serves as a reminder to stay vigilant and prioritize healthy sleep habits, especially in later life, to protect our lungs and ensure optimal well-being.

Dr. Camel's Conclusion

This study highlights the potential risks of intermittent hypoxia associated with obstructive sleep apnea in older individuals with idiopathic pulmonary fibrosis, emphasizing the need for early diagnosis and treatment to prevent further lung damage.

Date :
  1. Date Completed 2023-11-10
  2. Date Revised 2023-11-17
Further Info :

Pubmed ID

37793985

DOI: Digital Object Identifier

PMC10636542

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Languages

English

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