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Treatment Persistence of Apremilast Among Patients with Psoriatic Arthritis.

Author: BergmanIrina, CohenArnon Dov, FeldhamerIlan, HaddadAmir, LaviIdit, SalibaWalid, ShynkarLisa, SteinNili, ZismanDevy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A retrospective cohort study of 568 patients with psoriatic arthritis (PsA) treated with apremilast found a relatively low drug persistence, with 6-month and 1-year survival rates of 50.3% and 31.3%, respectively. Treatment discontinuation was mainly due to joint inefficacy. Further research is needed to improve patient selection and ensure treatment effectiveness and persistence.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Persistence in drug therapy reflects treatment effectiveness and tolerability. We aim to estimate the persistence of apremilast prescribed to patients with psoriatic arthritis (PsA) and to identify characteristics associated with treatment discontinuation in a real-world setting. METH...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560465/

データ提供：米国国立医学図書館（NLM）

Apremilast Persistence in Psoriatic Arthritis: Examining Factors Influencing Treatment Discontinuation

The journey to manage psoriatic arthritis, an inflammatory condition affecting the joints and skin, can be a long and winding road. This research delves into the persistence of apremilast, a medication commonly used to treat this condition, in a real-world setting. The authors examine the factors that contribute to treatment discontinuation, providing valuable insights into patient characteristics and medication adherence.

Understanding Treatment Adherence: Exploring the Factors Behind Apremilast Discontinuation

The study reveals that persistence on apremilast treatment for psoriatic arthritis is relatively low, with a median persistence period of 6.1 months. The authors identify several factors associated with treatment discontinuation, including lack of skin and joint efficacy and the occurrence of side effects. This information is crucial for understanding the challenges associated with long-term medication adherence in psoriatic arthritis.

Improving Treatment Outcomes: Identifying Strategies to Enhance Apremilast Persistence

The study's findings highlight the need for improved patient selection and strategies to address factors contributing to treatment discontinuation. By carefully evaluating patient characteristics and expectations, healthcare providers can potentially optimize treatment outcomes and enhance apremilast persistence. Addressing patient concerns regarding efficacy and side effects can also play a crucial role in improving medication adherence.

Dr.Camel's Conclusion

This study sheds light on the challenges associated with apremilast persistence in psoriatic arthritis. Understanding the factors that influence treatment discontinuation is critical for developing strategies to improve patient selection, address concerns regarding efficacy and side effects, and ultimately enhance long-term medication adherence. By addressing these issues, we can work towards improving the quality of life for individuals living with psoriatic arthritis.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-18
Further Info :

Pubmed ID

37814674

DOI: Digital Object Identifier

PMC10560465

SNS
PICO Info
in preparation
Languages

English

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