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Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS) Patients with Augmentation and/or Severe RLS Symptoms: A Report of 4 Cases.

Author: LeeElliott Kyung, RobillardRebecca, SpitaleNaomi

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case report describes four patients with restless legs syndrome (RLS) who developed augmentation after prolonged treatment with dopamine agonists. Treatment with aripiprazole, a dopamine receptor partial agonist, was successful in managing the augmentation symptoms.
Paper Details　
Original Abstract of the Article :
Restless Legs Syndrome (RLS) is a sensorimotor disorder associated with an unpleasant urge to move the limbs, relieved with movement, occurring in the evenings and with prolonged rest/inactivity. Treatment with dopamine agonists is effective for up to 60-90% of affected individuals. However, augment...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561607/

データ提供：米国国立医学図書館（NLM）

Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS) Patients with Augmentation and/or Severe RLS Symptoms: A Report of 4 Cases

This case report explores the use of aripiprazole, a dopamine receptor partial agonist (DRPA), in managing augmentation symptoms in patients with Restless Legs Syndrome (RLS). The authors present four cases of RLS patients who initially responded well to dopamine agonists but later developed augmentation, characterized by worsening RLS symptoms. Aripiprazole was successfully used to alleviate augmentation symptoms in these patients, suggesting its potential as a treatment option for this challenging aspect of RLS.

Aripiprazole: A potential oasis in the desert of augmentation

The case report highlights the potential of aripiprazole as a treatment option for RLS augmentation. The findings suggest that aripiprazole could be a valuable tool for managing this challenging aspect of RLS, offering relief for patients who have experienced worsening symptoms after prolonged dopamine agonist treatment.

Staying hydrated in the desert of RLS

As a wise camel, I understand the discomfort of Restless Legs Syndrome (RLS). This case report offers hope for patients experiencing augmentation, a challenging aspect of RLS. It's important to consult with a healthcare professional to explore all treatment options and develop a personalized plan for managing RLS.

Dr.Camel's Conclusion

The case report provides preliminary evidence for the potential efficacy of aripiprazole in managing RLS augmentation. While further research is needed to confirm its effectiveness and safety, aripiprazole may offer a valuable treatment option for patients who have experienced worsening RLS symptoms after prolonged dopamine agonist treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-30
Further Info :

Pubmed ID

37818170

DOI: Digital Object Identifier

PMC10561607

Related Literature

Article Analysis
・Side Effects of aripiprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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