Paper Details

  1. Home
  2. Paper Details

Protective Effects of Rivaroxaban on White Matter Integrity and Remyelination in a Mouse Model of Alzheimer's Disease Combined with Cerebral Hypoperfusion.

Author: BianYuting, BianZhihong, FukuiYusuke, HuXinran, IshiuraHiroyuki, LiuXia, MoriharaRyuta, SunHongming, YamashitaToru, YuHaibo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Alzheimer's disease (AD) is associated with white matter changes, and chronic cerebral hypoperfusion (CCH) can exacerbate AD progression. Rivaroxaban, an anticoagulant, has shown potential for reducing dementia rates in atrial fibrillation patients, but its impact on white matter and underlying mechanisms require further investigation.
Paper Details　
Original Abstract of the Article :
Alzheimer's disease (AD) is characterized by cognitive dysfunction and memory loss that is accompanied by pathological changes to white matter. Some clinical and animal research revealed that AD combined with chronic cerebral hypoperfusion (CCH) exacerbates AD progression by inducing blood-brain bar...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3233/JAD-230413

データ提供：米国国立医学図書館（NLM）

Rivaroxaban: A Potential Oasis in the Desert of Alzheimer's Disease?

Alzheimer's disease (AD) is a devastating neurodegenerative disease, characterized by cognitive decline and memory loss. The researchers in this study decided to explore the potential of rivaroxaban, an anticoagulant, in mitigating the effects of AD, particularly its impact on white matter integrity and remyelination. They investigated the protective effects of rivaroxaban in a mouse model of AD combined with cerebral hypoperfusion, a condition that reduces blood flow to the brain.

Rivaroxaban's Potential: A Glimpse of Hope in the Desert

The study found that rivaroxaban showed promising protective effects on white matter integrity and remyelination in the mouse model. These findings suggest that rivaroxaban could play a crucial role in protecting the brain from the damaging effects of AD. However, further research is needed to confirm these findings and to explore the clinical implications of rivaroxaban in treating AD.

Navigating Alzheimer's: A Journey of Research and Hope

This study offers a glimmer of hope in the fight against Alzheimer's disease. Rivaroxaban's potential to protect white matter integrity and promote remyelination is a significant finding. However, more research is needed to understand its full potential and to develop safe and effective treatment protocols. Just as a camel can navigate the desert with resilience, so can we, through continued research and collaboration, find ways to overcome the challenges of Alzheimer's disease.

Dr.Camel's Conclusion

Alzheimer's disease is like a vast and unforgiving desert, where memories fade and minds wander. Rivaroxaban, like a well-spring in the desert, offers a potential source of hope. This study suggests that rivaroxaban may offer protection against the damaging effects of AD. However, like a desert traveler, we must continue our journey of research and exploration to fully understand its potential.

Date :
  1. Date Completed 2023-11-14
  2. Date Revised 2023-11-22
Further Info :

Pubmed ID

37840489

DOI: Digital Object Identifier

10.3233/JAD-230413

Related Literature

Article Analysis
・Effects of rivaroxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.