Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons.

Author: BergendahlGenevieve, BerryDon, BrownValerie I, ClinchThomas, EslinDon E, FergusonWilliam, HansonDerek, HarrodVirginia L, IsakoffMichael S, KravekaJacqueline M, LorenziElizabeth, MitchellDeanna S, OesterheldJavier, RobertsWilliam, Saulnier ShollerGiselle L, WadaRandal K, ZagePeter

Paper Details 
Original Abstract of the Article :
Long-term survival in high-risk neuroblastoma (HRNB) is approximately 50%, with mortality primarily driven by relapse. Eflornithine (DFMO) to reduce risk of relapse after completion of immunotherapy was investigated previously in a single-arm, phase II study (NMTRC003B; ClinicalTrials.gov identifier...See full text at original site
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引用元:
https://doi.org/10.1200/JCO.22.02875

データ提供:米国国立医学図書館(NLM)

Eflornithine: A New Weapon in the Fight Against Neuroblastoma

Dr. Camel is always fascinated by the relentless pursuit of cures for childhood cancers. This study explores the potential of eflornithine (DFMO) as a post-immunotherapy maintenance treatment for high-risk neuroblastoma (HRNB). Researchers compared the survival outcomes of HRNB patients who received DFMO after immunotherapy to a historical control group that did not receive this treatment. This study aimed to assess the impact of DFMO on event-free survival (EFS) and overall survival (OS) in HRNB patients.

The Promise of Eflornithine

The results of this study suggest that DFMO may improve both EFS and OS in HRNB patients who have completed immunotherapy. These promising findings warrant further investigation to confirm the efficacy of DFMO as a post-immunotherapy maintenance treatment for HRNB. This could potentially lead to improved outcomes and long-term survival for children battling this challenging cancer.

A Glimpse of Hope for Children with Neuroblastoma

Dr. Camel believes that this research offers a valuable insight into the potential of DFMO to improve survival rates for children with HRNB. While more research is needed to confirm these findings, this study provides a glimmer of hope for families battling this devastating disease. By exploring novel treatment approaches, researchers may be able to make a significant difference in the lives of these children.

Dr. Camel's Conclusion

Dr. Camel finds this research truly inspiring. The relentless pursuit of effective treatments for childhood cancers is a testament to the dedication of researchers and clinicians working tirelessly to improve the lives of young patients. The potential of DFMO to improve survival outcomes for HRNB patients is a promising development in the fight against this challenging disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-26
Further Info :

Pubmed ID

37883734

DOI: Digital Object Identifier

10.1200/JCO.22.02875

Related Literature

SNS
PICO Info
in preparation
Languages

English

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