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Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.

Author: JiangNan, JinShangyi, LiMengtao, TianXinping, WangQian, YuChen, ZengXiaofeng, ZhaoJiuliang

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This network meta-analysis compared the efficacy and safety of various immunosuppressive regimens for lupus nephritis (LN). The combination of tacrolimus (TAC), mycophenolate mofetil (MMF), and glucocorticoid (GC) was the best regimen for improving the total remission rate and SLEDAI score. The choice of regimen for specific outcomes should be carefully considered for high-risk patients.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Various immunosuppressive regimens have been developed for the treatment of lupus nephritis (LN). This study aimed to compare the efficacy and safety of immunosuppressive regimens in adults with LN. METHODS: We systematically searched the PubMed, Embase, and Cochrane Central Register ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611487/

データ提供：米国国立医学図書館（NLM）

Navigating the Labyrinth of Lupus Nephritis: A Comparative Analysis of Immunosuppressive Regimens

Lupus nephritis, a serious complication of systemic lupus erythematosus, presents a significant challenge for clinicians. This research undertakes a comprehensive systematic review and network meta-analysis to compare the efficacy and safety of various immunosuppressive regimens used to treat lupus nephritis in adults. The study aims to guide treatment decisions by identifying the most effective and tolerable regimens for this challenging condition.

A Symphony of Medications: Finding the Right Rhythm for Lupus Nephritis

The meta-analysis reveals that different immunosuppressive regimens demonstrate varying levels of efficacy and safety. The combination of tacrolimus, mycophenolate mofetil, and glucocorticoid emerges as the most effective regimen for achieving total remission and reducing disease activity. The study also highlights the importance of considering specific outcomes when choosing a regimen, as different combinations excel in different areas, such as complete remission, relapse prevention, and reducing the risk of specific complications.

Living with Lupus Nephritis: Empowering Patients with Knowledge

This comprehensive research provides valuable insights for patients and clinicians alike. It underscores the importance of personalized treatment approaches for lupus nephritis, taking into account individual patient characteristics and specific treatment goals. By understanding the nuances of different immunosuppressive regimens, patients can partner with their healthcare providers to navigate this challenging condition with confidence.

Dr. Camel's Conclusion

This study serves as a valuable guide for navigating the complex landscape of lupus nephritis treatment. By providing a comprehensive comparison of immunosuppressive regimens, it empowers clinicians to make informed decisions and patients to advocate for their own healthcare needs. It is a testament to the power of evidence-based medicine in improving patient care.

Date :
  1. Date Completed 2023-10-31
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37901212

DOI: Digital Object Identifier

PMC10611487

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Languages

English

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