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Benefits of Macitentan in Patients with Pulmonary Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Author: HanDong, QinJinlv, WangGuizuo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This meta-analysis found that macitentan significantly improved various parameters in patients with pulmonary hypertension (PH), including 6-minute walk distance, pulmonary vascular resistance, mean pulmonary artery pressure, N-terminal pro-brain natriuretic peptide, and cardiac index. Macitentan is a promising treatment for PH, but further studies are needed to validate its effectiveness.
Paper Details　
Original Abstract of the Article :
BACKGROUND: This systematic review and meta-analysis aimed to determine the efficacy of macitentan in patients with pulmonary hypertension (PH). METHODS: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled tr...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607635/

データ提供：米国国立医学図書館（NLM）

Macitentan: A Promising Therapy for Pulmonary Hypertension

Pulmonary hypertension (PH) is a serious and often life-threatening condition that affects the arteries in the lungs. This systematic review and meta-analysis examine the efficacy of macitentan, an endothelin receptor antagonist, in treating PH. The researchers pooled data from six randomized controlled trials (RCTs) involving 1,003 participants, comparing macitentan to placebo. The results demonstrated significant improvements in various measures of PH severity in macitentan-treated patients, including 6-minute walk distance, pulmonary vascular resistance, mean pulmonary arterial pressure, N-terminal pro-B-type natriuretic peptide, and cardiac index.

Macitentan: A Potential Game-Changer for PH Treatment

This systematic review and meta-analysis provide strong evidence supporting the efficacy of macitentan in treating PH. The researchers found that macitentan significantly improved various measures of PH severity, suggesting its potential as an effective therapy for this challenging condition. The study highlights the importance of macitentan as a promising treatment option for PH, encouraging further validation of its efficacy and safety in larger clinical trials.

Advancing PH Treatment: A Focus on New Therapies

This research underscores the importance of developing new and effective therapies for PH. The study's findings on macitentan's efficacy provide hope for improving treatment outcomes for patients with this serious condition. Further research is crucial to confirm these findings, to optimize macitentan's use in clinical practice, and to develop additional therapies that address the unmet needs in PH management.

Dr. Camel's Conclusion

Just as a camel can navigate the harsh and unforgiving desert, researchers are continually striving to find new ways to treat PH. This systematic review and meta-analysis provide compelling evidence for the efficacy of macitentan, offering hope for a more effective and comprehensive approach to managing this challenging condition.

Date :
  1. Date Completed 2023-10-31
  2. Date Revised 2023-11-15
Further Info :

Pubmed ID

37901601

DOI: Digital Object Identifier

PMC10607635

Related Literature

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・Effects of macitentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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