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Lychnopholide loaded in surface modified polylactide nanocapsules (LYC-PLA-PEG-NC) cure mice infected by Trypanosoma cruzi strain a prototype of resistance to benznidazole and nifurtimox: First insights of its mechanism of action.

Author: BranquinhoRenata Tupinambá, LanaMarta de, MilagreMatheus Marques, MosqueiraVanessa Carla Furtado, PedrosaTamiles Caroline Fernandes, SampaioLarissa Silva, Saúde-GuimarãesDênia Antunes, TeixeiraGabriel Marques, TorchelsenFernanda Karoline Vieira da Silva

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the therapeutic efficacy of nanoencapsulated lychnopholide (LYC-NC) against Trypanosoma cruzi, the parasite causing Chagas disease. LYC-NC demonstrated activity against epimastigotes and amastigotes and exhibited therapeutic efficacy in mice infected with a resistant strain. The results suggest LYC-NC as a promising new therapeutic option for Chagas disease.
Paper Details　
Original Abstract of the Article :
Chagas disease (CD) remains neglected and causes high morbidity and mortality. The great difficulty is the lack of effective treatment. The current drugs cause side effects and have limited therapeutic efficacy in the chronic phase. This study aims to fulfil some gaps in studies of the natural subst...See full text at original site
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引用元：
https://doi.org/10.1016/j.exppara.2023.108647

データ提供：米国国立医学図書館（NLM）

New Hope for Chagas Disease

This research focuses on the development of a new treatment for Chagas disease, a neglected tropical disease caused by the parasite *Trypanosoma cruzi*. The study investigates the therapeutic potential of lychnopholide, a natural compound, when encapsulated in polylactide nanocapsules (LYC-PLA-PEG-NC). The researchers found that LYC-PLA-PEG-NC was effective in curing mice infected with a *T. cruzi* strain that is resistant to conventional treatments. The study also provides insights into the mechanism of action of lychnopholide.

Battling Chagas Disease in the Desert of Neglect

Chagas disease is like a hidden desert oasis, overlooked and neglected by many. This research sheds light on the importance of developing new treatments for this debilitating disease. The findings suggest that LYC-PLA-PEG-NC could be a promising new weapon in the fight against Chagas disease, offering hope for those affected by this neglected condition.

A New Tool for Fighting Parasitic Infections

This research highlights the potential of natural compounds, like lychnopholide, for treating parasitic infections. The use of nanocapsules to deliver these compounds offers a new and innovative approach to drug development. It's like finding a new wellspring of potential in the desert of parasitic diseases.

Dr.Camel's Conclusion

This study provides a beacon of hope in the fight against Chagas disease. LYC-PLA-PEG-NC represents a promising new treatment that could potentially transform the lives of those affected by this debilitating illness. It's like finding a hidden oasis in the desert of neglected diseases, bringing relief and a chance for a healthier future.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-11
Further Info :

Pubmed ID

37914151

DOI: Digital Object Identifier

10.1016/j.exppara.2023.108647

SNS
PICO Info
in preparation
Languages

English

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