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Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat.

Author: FujiiWataru, KimuraKoichi, KuwaharaMasayoshi, MoritaHiroyuki, NakanishiKoki, SaikaTakeru, SekizawaShin-Ichi, TochinaiRyota, TsuruYoshiharu, YamanouchiKeitaro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examines the potential of ivabradine as a treatment option for cardiomyopathy in patients with Duchenne muscular dystrophy (DMD) who experience tachycardia. Ivabradine, a drug that suppresses cardiac sinus node pacemakers without decreasing blood pressure, showed promising results in ameliorating cardiomyopathy progression in a rat model with DMD.
Paper Details　
Original Abstract of the Article :
Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy caused by dystrophin mutations. Inevitable progressive cardiomyopathy is a current leading cause of premature death although respiratory management has improved the prognosis of patients with DMD. Recent evidence shows that reducing...See full text at original site
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引用元：
https://doi.org/10.1538/expanim.23-0087

データ提供：米国国立医学図書館（NLM）

Duchenne Muscular Dystrophy: A Journey Through the Desert of Cardiomyopathy

Duchenne muscular dystrophy (DMD), a devastating genetic disorder, often leads to progressive cardiomyopathy, a weakening of the heart muscle. This research explores the potential of ivabradine, a heart rate-reducing medication, to alleviate cardiomyopathy progression in a rat model of DMD. The study investigates the effects of ivabradine on heart rate, blood pressure, and cardiomyopathy progression, aiming to identify a safe and effective treatment option for individuals with DMD.

Finding a New Path: Ivabradine and Cardiomyopathy in DMD

This research demonstrates the potential of ivabradine as a treatment for cardiomyopathy in DMD. The study found that ivabradine effectively reduced heart rate without significantly decreasing blood pressure, offering a safe and effective way to manage heart rate in individuals with DMD. The researchers also found that ivabradine could ameliorate cardiomyopathy progression in DMD rats, providing hope for better management of this challenging condition.

A Beacon of Hope: Ivabradine and DMD

This research offers a beacon of hope for individuals with DMD, demonstrating the potential of ivabradine to slow the progression of cardiomyopathy. The study found that ivabradine effectively reduced heart rate and could alleviate cardiomyopathy progression, offering a potential treatment option to improve the lives of those living with DMD. This research underscores the importance of continued research and development of effective therapies for genetic disorders.

Dr.Camel's Conclusion

This research is a testament to the ongoing quest for better treatments for Duchenne muscular dystrophy, a journey through the desert of cardiomyopathy. It highlights the potential of ivabradine to offer a new path to managing this challenging condition, providing hope for a brighter future for individuals with DMD. This research is a reminder that even in the most challenging landscapes, there is always the possibility of finding a cure.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-01
Further Info :

Pubmed ID

37914289

DOI: Digital Object Identifier

10.1538/expanim.23-0087

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Languages

English

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