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Severe lactic acidosis during tenofovir disoproxil fumarate and cobicistat combination for HIV patient.

Author: IsodaAtsushi, MatsumotoMorio, MiharaMasahiro, SawamuraMorio

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Lactic acidosis is a rare but serious side effect of tenofovir disoproxil fumarate (TDF), an antiretroviral medication used to treat HIV. The study reports a case of lactic acidosis in an underweight woman with HIV who was taking TDF with cobicistat. The patient's low body weight and the addition of cobicistat likely contributed to renal dysfunction, leading to higher tenofovir levels, mitochondrial damage, and lactic acidosis. The authors emphasize the need for careful monitoring of renal function and lactic acidosis in underweight HIV patients taking TDF-containing regimens, particularly when cobicistat is included.
Paper Details　
Original Abstract of the Article :
Lactic acidosis is a rare but serious side effect in individuals receiving nucleoside reverse transcriptase inhibitors. An underweight woman with HIV was admitted to our hospital because of nausea and diffuse myalgia. Her antiretroviral regimen had been changed to tenofovir disoproxil fumarate (TDF)...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626898/

データ提供：米国国立医学図書館（NLM）

Tenofovir Disoproxil Fumarate and Lactic Acidosis: A Cautionary Tale

The world of HIV treatment is a complex desert, with a constant search for new oases of hope. This case report explores a rare but serious side effect of [tenofovir disoproxil fumarate (TDF)], a common antiretroviral medication. The researchers describe a case of [severe lactic acidosis] in an underweight woman with HIV who was receiving a combination of TDF, emtricitabine, darunavir, and cobicistat. They hypothesized that [the patient's low body weight, combined with cobicistat, led to elevated tenofovir levels], contributing to mitochondrial damage and lactic acidosis. This case report highlights the importance of careful monitoring and individualized treatment approaches in managing HIV patients.

Tenofovir and Lactic Acidosis: A Balancing Act in HIV Treatment

This case report serves as a cautionary tale, reminding us of the potential risks associated with TDF, particularly in underweight patients. The desert of HIV treatment is full of complex considerations, and this research underscores the importance of careful monitoring and individualized care for patients receiving TDF-containing regimens.

Navigating the Desert of HIV Treatment: Prioritizing Patient Safety

This case report highlights the need for vigilance in monitoring HIV patients receiving TDF-containing regimens, especially those with low body weight. The desert of HIV treatment is full of potential challenges, and we must prioritize patient safety to ensure a smooth and healthy journey through treatment.

Dr. Camel's Conclusion

This case report emphasizes the importance of careful monitoring and individualized treatment approaches in managing HIV patients, particularly when using TDF-containing regimens. The desert of HIV treatment is full of complexities, and this research reminds us to navigate this terrain with caution and prioritize patient safety to ensure a healthy and fulfilling journey for those affected by this formidable disease.

Date :
  1. Date Completed 2023-11-15
  2. Date Revised 2023-11-15
Further Info :

Pubmed ID

37923339

DOI: Digital Object Identifier

PMC10626898

Related Literature

Article Analysis
・Effects of cobicistat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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