Trifluridine/Tipiracil Plus Bevacizumab for Vulnerable Patients With Pretreated Metastatic Colorectal Cancer: A Retrospective Study (WJOG14520G).

Author: AkiyoshiKohei, ChibaYasutaka, HasegawaHiroko, HironakaShuichi, KatsuyaHiroo, KawakamiHisato, KawakamiTakeshi, KitoYosuke, KumanishiRyosuke, MatsumotoToshihiko, MitaniSeiichiro, MuroKei, NishinaShinichi, NishinaTomohiro, OhtaTakashi, ShimokawaHozumi, ShinoharaYudai, TsuzukiTakao, YamazakiKentaro

Paper Details 
Original Abstract of the Article :
BACKGROUND: Trifluridine/tipiracil (FTD/TPI) plus bevacizumab has shown clinical benefit for metastatic colorectal cancer (mCRC) refractory to standard therapy. However, few data have been available for patients with pretreated mCRC who are intolerant of intensive therapy (vulnerable). METHODS: We ...See full text at original site
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引用元:
https://doi.org/10.1093/oncolo/oyad296

データ提供:米国国立医学図書館(NLM)

Trifluridine/Tipiracil Plus Bevacizumab for Vulnerable Patients With Pretreated Metastatic Colorectal Cancer: A Beacon of Hope in the Desert of Cancer

Metastatic colorectal cancer, my dear friends, is a formidable adversary, like a relentless sandstorm in the body. This study, like a skilled desert guide, explores the potential of a combination therapy involving trifluridine/tipiracil (FTD/TPI) plus bevacizumab for patients with advanced colorectal cancer who have already undergone previous treatments. The researchers are seeking to find new and effective weapons to fight this devastating disease, especially for patients who are vulnerable due to age, comorbidities, or weakened health.

A New Weapon in the Fight Against Colorectal Cancer: A Glimpse of Hope

The study, a retrospective analysis of 93 patients, found that FTD/TPI plus bevacizumab demonstrated promising efficacy and a manageable safety profile in this vulnerable population. The objective response rate, while modest, was encouraging, and the disease control rate was even more significant. This is a beacon of hope in the desert of cancer, suggesting that this combination therapy may offer a lifeline for patients who have exhausted other treatment options. The researchers are careful to note that this was a retrospective study and larger prospective trials are needed to further confirm these findings.

Navigating the Desert of Cancer Treatment: A Journey of Hope and Resilience

This research offers a glimmer of hope for vulnerable patients with pretreated metastatic colorectal cancer. The combination therapy of FTD/TPI plus bevacizumab shows potential for extending survival and improving quality of life, offering a respite in the desert of this challenging disease. It is a reminder that even in the face of adversity, we must continue to seek new and innovative treatments, embracing a spirit of resilience and hope.

Dr.Camel's Conclusion

This study provides a promising glimpse into the potential of FTD/TPI plus bevacizumab for vulnerable patients with advanced colorectal cancer. While further research is needed, this study offers a beacon of hope in the fight against this disease. It is a testament to the unwavering spirit of research and the ongoing quest for better treatments for those facing life-threatening illnesses.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

37950903

DOI: Digital Object Identifier

10.1093/oncolo/oyad296

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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