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Safety assessment of Brexpiprazole: Real-world adverse event analysis from the FAERS database.

Author: JiYingying, JiangYing, ShenYuan, ZhouLingyun, ZhouQin, ZhuHaohao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed adverse drug events (ADE) related to Brexpiprazole from 2015 Q3 to 2023 Q1 using the FAERS database. It identified various ADE signals, including Metabolism and nutrition disorders and Reproductive system and breast disorders, which were not previously mentioned in the official drug label. It also found that Tardive dyskinesia and Extrapyramidal disorder were common and strong ADE signals. The study highlights the need for close monitoring of psychiatric disorders, metabolic and nutritional disorders, reproductive system and breast disorders, and other events during Brexpiprazole treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: This study aims to analysis adverse drug events (ADE) related to Brexpiprazole from the third quarter of 2015 to the first quarter of 2023 from FAERS database. METHODS: The ADE data related to Brexpiprazole from 2015 Q3 to 2023 Q1 were collected. After standardizing the data, a variety o...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2023.11.025

データ提供：米国国立医学図書館（NLM）

A Comprehensive Safety Assessment of Brexpiprazole

This research takes a deep dive into the safety profile of [Brexpiprazole], a medication used to treat certain mental health conditions. The study analyzed data from the [FAERS database] to identify potential [adverse drug events (ADE)] associated with this drug.

Brexpiprazole’s Potential Side Effects

The analysis revealed a wide range of potential side effects, including [metabolism and nutrition disorders], [reproductive system and breast disorders], [egocentrism], [pharmacophobia], and [compulsions]. The study also highlighted the potential for [tardive dyskinesia] and [extrapyramidal disorder] – serious movement disorders.

Navigating the Complexities of Medication

Just like the intricate network of sand dunes in a desert, the potential effects of medications can be complex and multifaceted. This research serves as a valuable reminder of the importance of careful monitoring and understanding the potential risks associated with medications. It emphasizes the need for close collaboration between patients and healthcare providers to ensure safe and effective treatment.

Dr.Camel's Conclusion

This research reinforces the importance of vigilant monitoring when prescribing Brexpiprazole. Just as a camel navigates the treacherous desert, healthcare providers must navigate the complex terrain of potential side effects and strive to provide safe and effective treatment for their patients.
Date :
  1. Date Completed 2023-12-04
  2. Date Revised 2023-12-04
Further Info :

Pubmed ID

37956832

DOI: Digital Object Identifier

10.1016/j.jad.2023.11.025

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・Side Effects of brexpiprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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