Effect of Regular Consumption of a Miraculin-Based Food Supplement on Taste Perception and Nutritional Status in Malnourished Cancer Patients: A Triple-Blind, Randomized, Placebo-Controlled Clinical Trial-CLINMIR Pilot Protocol.

Author: Bensadon-NaederLoan, Feliú-BatlleJaime, GilÁngel, HummelThomas, López-PlazaBricia, Menéndez-ReyAdrián, Palma-MillaSamara

Paper Details 
Original Abstract of the Article :
Taste disorders are common among cancer patients undergoing chemotherapy, with a prevalence ranging from 20% to 86%, persisting throughout treatment. This condition leads to reduced food consumption, increasing the risk of malnutrition. Malnutrition is associated not only with worse treatment effica...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648678/

データ提供:米国国立医学図書館(NLM)

Improving Taste Perception in Malnourished Cancer Patients

The world of cancer treatment is vast and complex, with a plethora of challenges for patients. One such challenge is taste disorders, which can be a significant barrier to adequate nutrition. This is especially true for malnourished cancer patients undergoing chemotherapy. These patients are at higher risk of experiencing taste distortions, leading to a reduced appetite and subsequent nutritional deficiencies. The consequences of malnutrition can be severe, impacting treatment efficacy, disease prognosis, and overall quality of life. The CLINMIR Pilot Protocol is a groundbreaking study focusing on the potential of miraculin, a taste-modifying protein found in the miracle berry, to improve taste perception and nutritional status in malnourished cancer patients.

Miraculin: A Potential Game-Changer for Cancer Patients

The study is designed as a triple-blind, randomized, placebo-controlled clinical trial, with 30 patients divided into three groups, each receiving a different dose of miraculin-based food supplement or a placebo. Researchers will meticulously assess various parameters related to taste perception, nutritional status, and overall health over a period of three months. This includes measuring electrical and chemical taste perception, smell perception, nutritional assessment, dietary habits, quality of life, and even analyzing the fatty acid profile of erythrocytes, inflammatory and cancer-associated cytokines, oxidative stress, and the gut microbiota.

A Ray of Hope for Malnourished Cancer Patients

The primary anticipated result is a significant improvement in food taste perception among malnourished cancer patients with taste distortion. This improvement could translate into increased food intake, ultimately leading to an improvement in their nutritional status and mitigating the associated risks. The study also aims to identify the optimal dosage of the miraculin-based food supplement for maximum benefits. The CLINMIR Protocol is a beacon of hope for malnourished cancer patients, offering a potential solution to a major obstacle in their journey towards recovery.

Dr.Camel's Conclusion

It's like finding a hidden oasis in the vast desert of cancer treatment! This study holds the key to unlocking better nutrition for cancer patients struggling with taste disorders. By harnessing the power of miraculin, researchers are seeking to nourish both the body and the spirit, leading to a more positive and sustainable path towards recovery. The journey of cancer treatment can be long and arduous, but the potential for miraculin to alleviate taste distortions and improve nutritional status offers a ray of hope for these patients.

Date :
  1. Date Completed 2023-11-15
  2. Date Revised 2023-11-17
Further Info :

Pubmed ID

37960292

DOI: Digital Object Identifier

PMC10648678

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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