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Safety of cinacalcet in children and adolescents with chronic kidney disease-mineral bone disorder: systematic review and proportional meta-analysis of case series.

Author: CaramoriJacqueline Costa Teixeira, RiyuzoMarcia Camegaçava, TakaseHenrique Mochida, ZamonerSoraya Mayumi Sasaoka, de AndradeLuis Gustavo Modelli

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the use of cinacalcet, a calcimimetic drug, in children with chronic kidney disease (CKD) and the concerns about its safety in this population.
Paper Details　
Original Abstract of the Article :
Mineral and bone disease in children with chronic kidney disease can cause abnormalities in calcium, phosphorus, parathyroid hormone, and vitamin D and when left untreated can result in impaired growth, bone deformities, fractures, and vascular calcification. Cinacalcet is a calcimimetic widely used...See full text at original site
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引用元：
https://doi.org/10.1007/s11255-023-03844-2

データ提供：米国国立医学図書館（NLM）

Cinacalcet: A Safe Choice for Children with Chronic Kidney Disease?

This systematic review examines the safety of [cinacalcet], a calcimimetic drug used to manage [parathyroid hormone] levels in adults with [chronic kidney disease]. The study focuses on the pediatric population, where data on cinacalcet's safety is limited due to a lack of randomized clinical trials.

Navigating the Uncertainties of Pediatric Cinacalcet Use

While cinacalcet is widely used in adults, its safety in children with chronic kidney disease remains a concern. The authors conducted a [systematic review and proportional meta-analysis] of case series, revealing the scarcity of robust data for pediatric use.

Navigating the Uncertainties of Pediatric Cinacalcet Use

This review underscores the need for further research into the safety of cinacalcet in children with chronic kidney disease. Like a camel carefully navigating a treacherous desert landscape, healthcare professionals need to proceed with caution when using cinacalcet in pediatric patients, ensuring that the potential benefits outweigh the risks.

Dr. Camel's Conclusion

The journey of pediatric medicine is often marked by uncertainties. This review highlights the need for careful consideration and further research when using cinacalcet in children with chronic kidney disease. We must approach this challenging landscape with a cautious and evidence-based approach, ensuring the well-being of our youngest patients.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-14
Further Info :

Pubmed ID

37964112

DOI: Digital Object Identifier

10.1007/s11255-023-03844-2

Related Literature

Article Analysis
・Side Effects of cinacalcet
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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