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Mirabegron displays anticancer effects by globally browning adipose tissues.

Author: CaoYihai, DengJinxiu, GeMinghua, HeXingkang, HuangPing, JingXu, LiSen, LiXiaokun, MuZepeng, SekiTakahiro, SuiWenhai, SunXiaoting, WangYangang, WuJieyu, XieSisi, YangYunlong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that mirabegron, a drug used to treat overactive bladders, can effectively treat various cancers by browning adipose tissues. This process increases energy expenditure and reduces tumor growth. The study suggests that mirabegron represents a new paradigm for treating cancer by targeting adipose metabolism.
Paper Details　
Original Abstract of the Article :
Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion, and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain largel...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665320/

データ提供：米国国立医学図書館（NLM）

Mirabegron and Adipose Tissue Browning for Cancer Treatment

This research explores a novel approach to cancer treatment by targeting adipose tissue metabolism. The study investigates the anticancer effects of mirabegron, a drug commonly used for overactive bladders, by inducing browning of adipose tissues. The researchers demonstrate the potential of mirabegron in treating various cancer types through its ability to activate thermogenesis in adipose tissues.

Mirabegron: A New Oasis in Cancer Treatment

This research suggests that mirabegron, a drug originally developed for overactive bladders, may have a significant role in cancer treatment. The study demonstrates that mirabegron induces browning of adipose tissues, leading to a reduction in tumor growth in various animal cancer models. This finding highlights the potential of mirabegron as a repurposed drug for treating a wide range of cancers.

Cancer and Metabolism: A Shifting Desert Landscape

The study underscores the importance of understanding the complex interplay between cancer and metabolism. The findings suggest that targeting adipose tissue metabolism could be a promising strategy for cancer treatment. This approach represents a shift in our understanding of cancer biology and offers new avenues for drug development and personalized medicine.

Dr. Camel's Conclusion

This research is like a new oasis emerging in the desert of cancer research. The study's findings offer a refreshing perspective on cancer treatment, suggesting that targeting adipose tissue metabolism could be a promising strategy for combating this disease.
Date :
  1. Date Completed 2023-11-27
  2. Date Revised 2023-11-27
Further Info :

Pubmed ID

37993438

DOI: Digital Object Identifier

PMC10665320

Related Literature

Article Analysis
・Effects of mirabegron
SNS
PICO Info
in preparation
Languages

English

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