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Daptomycin-Impregnated PMMA Cement against Vancomycin-Resistant Germs: Dosage, Handling, Elution, Mechanical Stability, and Effectiveness.

Author: AltVolker, DomannEugen, FölschChristian, HumezMartina, KühnKlaus-Dieter, StrathausenRainer, ThormannKai M, VogtSebastian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This in vitro study investigated the mechanical stability, handling properties, elution behavior, and antimicrobial effectiveness of PMMA cement loaded with different concentrations of daptomycin. The findings demonstrate its potential as a promising alternative to conventional antibiotic-loaded bone cement for treating infections caused by vancomycin-resistant pathogens.
Paper Details　
Original Abstract of the Article :
The number of periprosthetic joint infections caused by vancomycin-resistant pathogens is increasing. Currently, no PMMA cement is commercially available to cover VRE. Daptomycin shows promising results in treating infection, offering a good safety profile and a reduced risk of developing resistance...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668807/

データ提供：米国国立医学図書館（NLM）

Fighting Vancomycin-Resistant Infections: Daptomycin-Impregnated PMMA Cement

The rise of vancomycin-resistant pathogens poses a significant challenge in the fight against periprosthetic joint infections. This study explores the potential of using daptomycin-impregnated PMMA cement as a new weapon against these infections.

Daptomycin-Loaded Cement: Mechanical Stability and Antibacterial Effects

This in vitro study investigated the mechanical stability, handling properties, elution behavior, and antimicrobial effectiveness of PMMA cement loaded with different daptomycin concentrations. The findings suggest that daptomycin-loaded cement shows promising results in terms of mechanical stability, handling, and antibacterial activity.

A New Frontier in Infection Control

This research offers a potential solution for combating vancomycin-resistant infections. Just as a camel adapts to survive in harsh desert conditions, the medical community is continuously seeking innovative ways to combat infections.

Dr.Camel's Conclusion

This study presents a promising approach to treating infections caused by vancomycin-resistant bacteria. The use of daptomycin-impregnated PMMA cement demonstrates the ongoing quest for innovative solutions in the field of infectious disease control.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-26
Further Info :

Pubmed ID

37998769

DOI: Digital Object Identifier

PMC10668807

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in preparation
Languages

English

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