Switching to ozanimod as a strategy to adjust fingolimod-related lymphopenia.

Author: Brescia MorraVincenzo, CaliendoDaniele, CarotenutoAntonio, GrassiaMaria Carmela, LanzilloRoberta, MocciaMarcello, PetraccaMaria

Paper Details 
Original Abstract of the Article :
Fingolimod is a disease-modifying therapy for multiple sclerosis (MS) that modulates sphingosine 1-phospate receptors, impeding the egress of lymphocytes from lymphnodes and thus causing lymphopenia. Severe lymphopenia should lead to fingolimod discontinuation. We aim to evaluate whether switching f...See full text at original site
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引用元:
https://doi.org/10.1016/j.msard.2023.105135

データ提供:米国国立医学図書館(NLM)

Switching to Ozanimod: A Potential Strategy for Fingolimod-Related Lymphopenia

Fingolimod, a disease-modifying therapy for multiple sclerosis (MS), effectively manages the disease but can sometimes cause lymphopenia, a decrease in lymphocyte count. This research investigates whether switching from fingolimod to ozanimod, another MS treatment, could be a viable strategy to address fingolimod-related lymphopenia while maintaining clinical efficacy. The researchers aim to evaluate the feasibility and effectiveness of this treatment switch, seeking to provide a potential solution for patients experiencing fingolimod-induced lymphopenia.

Finding a Balance: Switching Therapies to Address Lymphopenia

This research explores a potential solution to a common challenge faced by patients taking fingolimod. The researchers hypothesize that switching to ozanimod could effectively address fingolimod-related lymphopenia while maintaining the therapeutic benefits of treating MS. This approach could potentially allow patients to continue receiving effective treatment for MS without experiencing the negative side effects of lymphopenia. It's like a camel encountering a harsh desert storm, seeking a sheltered oasis where it can find respite and continue its journey.

A New Path Forward: Optimizing Treatment for MS

This research offers a promising avenue for optimizing treatment for individuals with MS. It highlights the potential for switching therapies to address specific side effects while maintaining clinical efficacy. This approach could lead to more personalized and effective treatment plans for patients with MS, potentially improving their overall quality of life. It's like a camel navigating a diverse desert landscape, adjusting its route to avoid obstacles and reach its destination.

Dr. Camel's Conclusion

This study explores the potential of switching from fingolimod to ozanimod as a strategy to address fingolimod-related lymphopenia in MS patients. It's like a camel finding a new trail in the desert, offering a safer and more efficient route to its destination. This research highlights the importance of individualized treatment approaches for MS, recognizing that each patient may require a unique strategy to optimize their care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-25
Further Info :

Pubmed ID

38006850

DOI: Digital Object Identifier

10.1016/j.msard.2023.105135

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