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Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study.

Author: BrümmendorfTim H, CastagnettiFausto, ErnstThomas, Gambacorti-PasseriniCarlo, GilesFrancis J, Giraldo-CastellanoPilar, GjertsenBjörn T, HochhausAndreas, KuttschreuterLuke, PurcellSimon, RostiGianantonio, ZhaoHuadong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reports the efficacy and safety of bosutinib in patients with pretreated chronic myeloid leukemia (CML) after ≥3 years of follow-up. Patients <65 years of age and those with lower comorbidity burden had better outcomes. Older patients (≥75 years) and those with high comorbidity burden may require more careful monitoring due to an increased risk of adverse events.
Paper Details　
Original Abstract of the Article :
In the phase 4 BYOND trial, patients with pretreated chronic myeloid leukemia (CML) received bosutinib (starting dose: 500 mg/day). Efficacy and safety after ≥3 years of follow-up in 156 patients with Philadelphia chromosome-positive chronic phase CML by age and Charlson Comorbidity Index scores (wi...See full text at original site
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引用元：
https://doi.org/10.1038/s41375-023-02080-y

データ提供：米国国立医学図書館（NLM）

Bosutinib in Chronic Myeloid Leukemia: Exploring Age and Comorbidities

Chronic myeloid leukemia (CML) is a type of blood cancer that requires long-term treatment. This study examines the efficacy and safety of bosutinib, a tyrosine kinase inhibitor, in patients with pretreated CML, considering age and comorbidity burden. The researchers found that bosutinib was effective in achieving and maintaining cytogenetic and molecular responses across different age groups and comorbidity levels. However, older patients and those with higher comorbidity scores experienced more adverse events. This research highlights the importance of individualized treatment approaches in CML management.

Navigating the Desert of CML Treatment: A Personalized Path

This study is like navigating a diverse desert landscape, with varying terrains and challenges. The researchers explored the effects of bosutinib in patients with CML, accounting for age and comorbidities, highlighting the need for personalized treatment approaches. This reminds us that finding the right path in the desert of CML treatment is crucial, and it requires considering individual factors.

Managing CML: A Collaborative Approach

This research emphasizes the importance of close monitoring and individualized care for patients with CML. It's a reminder that a collaborative approach involving healthcare providers and patients is essential for achieving the best outcomes. This research also highlights the need for ongoing research to optimize treatment strategies and improve the quality of life for CML patients.

Dr. Camel's Conclusion

This study underscores the complex nature of CML treatment and the importance of personalized care. It's a reminder that navigating the desert of CML requires a collaborative approach, considering individual factors and adapting treatment strategies for optimal outcomes.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-25
Further Info :

Pubmed ID

38007586

DOI: Digital Object Identifier

10.1038/s41375-023-02080-y

Related Literature

Article Analysis
・Effects of bosutinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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