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The immunogenicity and the safety of the adjuvanted glycoprotein E (gE)-based recombinant vaccine against herpes zoster (RZV) in cancer patients during immunotherapy.
Author: AlaimoDomiziana, AlessioNicolò, BaldantiFausto, BergamiFederica, CassanitiIrene, ComolliGiuditta, DaucciaChiara, LasagnaAngioletta, MeleDalila, MuzziAlba, NovelliViola, PasiFrancesca, PedrazzoliPaolo
Original Abstract of the Article :
Herpes zoster (HZ) is caused by the reactivation of latent varicella zoster virus (VZV). Severe immunocompromising conditions, such as solid tumors, have been largely associated with an increased risk for HZ due to waning VZV-specific cellular immunity. With the approval of the adjuvanted glycoprote...See full text at original site
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引用元：
https://doi.org/10.1080/21645515.2023.2288282
データ提供：米国国立医学図書館（NLM）
Boosting Immunity in Cancer Patients: A New Approach to Herpes Zoster
The field of immunology is constantly evolving, with new advancements in understanding and treating diseases. This study delves into the crucial area of herpes zoster (HZ) vaccination, a concern for cancer patients undergoing immunotherapy. It employed a research approach that involved a clinical trial to investigate the immunogenicity of a glycoprotein E (gE)-based recombinant vaccine, RZV, in cancer patients during immunotherapy. The researchers aimed to assess the immune response in patients, a key factor in determining vaccine efficacy. The study revealed a significant portion of patients exhibited a robust humoral and cell-mediated immune response after the vaccination schedule. These findings highlight the potential of RZV to provide immunity against HZ, even in immunocompromised individuals like cancer patients.
A Strong and Long-Lasting Defense: Evidence for RZV's Efficacy
The research results indicate that RZV can induce a robust immune response in cancer patients undergoing immunotherapy. This is promising news, as these individuals are often at increased risk for HZ due to weakened immune systems. The fact that the immune response remained mostly stable over six months post-vaccination suggests a long-lasting protective effect.
Protecting Against Herpes Zoster: A Step Towards Better Health
The study highlights the importance of vaccination for cancer patients undergoing immunotherapy. The finding that RZV can induce a strong and durable immune response suggests that this vaccine can effectively protect individuals from the debilitating effects of HZ. This is a vital step towards better health and well-being for cancer patients.
Dr.Camel's Conclusion
Imagine a vast desert, where immunity is a precious oasis. Cancer treatments can often leave the immune system parched, making it vulnerable to diseases like herpes zoster. This research shows that RZV, like a refreshing spring, can revitalize the immune system, offering a much-needed defense against HZ. This is a remarkable step forward in protecting vulnerable individuals from the harsh realities of this disease.
Date :
- Date Completed 2023-12-04
- Date Revised 2023-12-04
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