Anti-ischemic and pleiotropic effects of ranolazine in chronic coronary syndromes.

Author: AthanasiosManolis, CostasThomopoulos, LeonidasPoulimenos, ManolisKallistratos

Paper Details 
Original Abstract of the Article :
The vast majority of antianginal drugs decrease heart rate and or blood pressure levels or the inotropic status of the left ventricle to decrease MVO2 and thus anginal symptoms. Ranolazine presents a completely different mechanism of action, which reduces the sodium-dependent calcium overload inhibi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.amjms.2023.12.001

データ提供:米国国立医学図書館(NLM)

Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes

The field of [cardiovascular medicine] is constantly striving to develop more effective treatments for [chronic coronary syndromes (CCS)]. This study explores the [anti-ischemic] and [pleiotropic effects] of [ranolazine], a drug that inhibits the [late sodium current], in patients with CCS. The researchers reviewed the available data on the clinical benefits of ranolazine.

Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes

The study highlights the unique mechanism of action of [ranolazine], which differs from traditional [antianginal drugs] that primarily target [heart rate], [blood pressure], or [inotropy]. Ranolazine's ability to [reduce sodium-dependent calcium overload] provides a novel approach to managing [anginal symptoms]. In addition to its [antianginal effects], the researchers highlight the [favorable effects] of ranolazine in [decreasing arrhythmic burden] and [ameliorating glycemic profile] in patients with CCS.

Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes

This review underscores the potential benefits of [ranolazine] as a [pleiotropic agent] for [CCS]. The study's findings suggest that ranolazine offers [multifaceted benefits] beyond [angina relief], potentially improving overall [cardiovascular health] in patients with CCS. Further research is needed to fully understand the long-term effects of ranolazine and to optimize its use in clinical practice.

Dr. Camel's Conclusion

Just as camels are known for their ability to navigate challenging terrain, we must navigate the complexities of cardiovascular disease with innovative approaches. This research highlights the potential of ranolazine as a valuable tool for managing chronic coronary syndromes, offering a multifaceted approach to improve patient outcomes.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-10
Further Info :

Pubmed ID

38072070

DOI: Digital Object Identifier

10.1016/j.amjms.2023.12.001

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.