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Anti-ischemic and pleiotropic effects of ranolazine in chronic coronary syndromes.
Author: AthanasiosManolis, CostasThomopoulos, LeonidasPoulimenos, ManolisKallistratos
Original Abstract of the Article :
The vast majority of antianginal drugs decrease heart rate and or blood pressure levels or the inotropic status of the left ventricle to decrease MVO2 and thus anginal symptoms. Ranolazine presents a completely different mechanism of action, which reduces the sodium-dependent calcium overload inhibi...See full text at original site
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引用元:
https://doi.org/10.1016/j.amjms.2023.12.001
データ提供:米国国立医学図書館(NLM)
Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes
The field of [cardiovascular medicine] is constantly striving to develop more effective treatments for [chronic coronary syndromes (CCS)]. This study explores the [anti-ischemic] and [pleiotropic effects] of [ranolazine], a drug that inhibits the [late sodium current], in patients with CCS. The researchers reviewed the available data on the clinical benefits of ranolazine.
Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes
The study highlights the unique mechanism of action of [ranolazine], which differs from traditional [antianginal drugs] that primarily target [heart rate], [blood pressure], or [inotropy]. Ranolazine's ability to [reduce sodium-dependent calcium overload] provides a novel approach to managing [anginal symptoms]. In addition to its [antianginal effects], the researchers highlight the [favorable effects] of ranolazine in [decreasing arrhythmic burden] and [ameliorating glycemic profile] in patients with CCS.
Ranolazine: A Pleiotropic Agent for Chronic Coronary Syndromes
This review underscores the potential benefits of [ranolazine] as a [pleiotropic agent] for [CCS]. The study's findings suggest that ranolazine offers [multifaceted benefits] beyond [angina relief], potentially improving overall [cardiovascular health] in patients with CCS. Further research is needed to fully understand the long-term effects of ranolazine and to optimize its use in clinical practice.
Dr. Camel's Conclusion
Just as camels are known for their ability to navigate challenging terrain, we must navigate the complexities of cardiovascular disease with innovative approaches. This research highlights the potential of ranolazine as a valuable tool for managing chronic coronary syndromes, offering a multifaceted approach to improve patient outcomes.
Date :
- Date Completed n.d.
- Date Revised 2023-12-10
Further Info :
Related Literature
English
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