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Side effects of phenobarbital in toddlers; behavioral and cognitive aspects.

Author: CamfieldC S, CamfieldP R, ChaplinS, CummingsC, DoyleA B, ShapiroS H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Phenobarbital is effective in treating febrile seizures in toddlers. However, it may have detrimental effects on memory and comprehension.
Paper Details　
Original Abstract of the Article :
Cognitive and behavioral effects of phenobarbital in toddlers were assessed in a randomized, placebo-controlled study of patients who had had a febrile seizure. There were no significant differences in IQ (Binet or Bayley Scales) between placebo and phenobarbital groups after eight to 12 months of t...See full text at original site
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引用元：
https://doi.org/10.1016/s0022-3476(79)80507-7

データ提供：米国国立医学図書館（NLM）

Phenobarbital and its Effects on Toddlers: A Balancing Act

This study delves into the complex landscape of pediatric medicine, investigating the effects of phenobarbital, a commonly used anti-seizure medication, on toddlers. The researchers, like skilled pediatricians carefully monitoring their young patients, sought to understand the potential cognitive and behavioral side effects of phenobarbital treatment.

Phenobarbital's Impact on Cognitive and Behavioral Development

The study found that while phenobarbital treatment did not significantly affect IQ scores, it did have detrimental effects on memory and comprehension. The researchers also observed increased fussiness and sleep disturbances in some toddlers treated with phenobarbital. This suggests that phenobarbital treatment, while effective in controlling seizures, can have a complex impact on young developing brains, much like a desert oasis can be both a source of life and a potential danger if not carefully managed.

Minimizing Negative Effects of Phenobarbital

The researchers emphasized the importance of minimizing the duration and dosage of phenobarbital treatment to reduce negative cognitive and behavioral effects. This is like carefully managing the use of precious water resources in a desert environment. The study highlights the crucial role of careful monitoring and intervention in pediatric medicine, ensuring that the benefits of treatment outweigh the potential risks.

Dr. Camel's Conclusion

This study provides valuable insights into the complex landscape of pediatric medicine. The researchers, like skilled pediatricians carefully monitoring their young patients, identified the potential cognitive and behavioral side effects of phenobarbital treatment. Their findings underscore the importance of carefully considering the potential benefits and risks of medication in young children, much like a wise traveler navigates the vast and sometimes treacherous desert landscape.
Date :
  1. Date Completed 1979-10-26
  2. Date Revised 2019-06-30
Further Info :

Pubmed ID

381616

DOI: Digital Object Identifier

10.1016/s0022-3476(79)80507-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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