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Biotransformation of primaquine in vitro with human K562 and bone marrow cells.

Author: AhmadT, CarsonP E, ChowH S, FrischerH, KaizerH, MellovitzR, NoraM V, ParkhurstG W, PtakL, SivarajanM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Primaquine metabolism can be studied in vitro using human erythroleukemic K562 cells. The study demonstrated that primaquine is metabolized into carboxyprimaquine in vitro and that this process can be blocked by BCNU.
Paper Details　
Original Abstract of the Article :
Although the antimalarial activity, hemolytic and methemoglobinemic side effects, and detoxification of primaquine are all thought to depend on various biotransformation products of the drug, their site and mechanism of formation and degradation are unknown and their specific biologic effects remain...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3819579

データ提供：米国国立医学図書館（NLM）

Exploring the Biotransformation of Primaquine

The field of [Pharmacology] is constantly seeking to understand the intricate ways in which drugs interact with the body. This study investigated the [Biotransformation] of [Primaquine], an antimalarial drug, in [Human K562 and Bone Marrow Cells]. The researchers conducted [In Vitro Studies] and found that [Primaquine] is rapidly and predominantly converted into [Carboxyprimaquine (CPQ)] in both [Human K562 Cells] and [Bone Marrow Cells].

Unveiling the Metabolic Pathways of Primaquine

This study sheds light on the [Metabolic Pathways] involved in the [Biotransformation] of [Primaquine]. The discovery that [CPQ] is the primary metabolite of [Primaquine] in both [Human K562 Cells] and [Bone Marrow Cells] is a significant finding. This information could be valuable for understanding the [Antimalarial Activity] and [Toxicity] of [Primaquine], potentially leading to the development of safer and more effective drug formulations.

The Complexity of Drug Metabolism

The study underscores the complexity of [Drug Metabolism] and the importance of understanding these processes. Just like the vast desert, the human body is full of hidden pathways and intricate interactions. By carefully studying the [Biotransformation] of drugs, we can gain a deeper understanding of how medications work and how to maximize their effectiveness while minimizing their adverse effects.

Dr.Camel's Conclusion

The study explores the biotransformation of primaquine in vitro with human K562 and bone marrow cells. The researchers found that primaquine is rapidly and predominantly converted into carboxyprimaquine (CPQ) in both cell types. This information could be valuable for understanding the antimalarial activity and toxicity of primaquine, potentially leading to the development of safer and more effective drug formulations.

Date :
  1. Date Completed 1987-04-20
  2. Date Revised 2018-02-06
Further Info :

Pubmed ID

3819579

DOI: Digital Object Identifier

0022-2143(87)90113-2

Related Literature

Article Analysis
・Side Effects of primaquine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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