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Therapeutic effects of PS-K and busulfan on the recurrent and metastatic diseases after the surgical removal of 3-methylcholanthrene-induced autochthonous tumors in C57BL/6 mice.

Author: HosokawaM, KobayashiH, MizukoshiT, SugawaraM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

PS-K and busulfan are effective in reducing tumor recurrence and metastasis in mice.
Paper Details　
Original Abstract of the Article :
The effectiveness of a protein-bound polysaccharide, PS-K, and an immunoaugmenting antileukemia agent, busulfan (BU), was investigated for the treatment of autochthonous tumors induced by 3-methylcholanthrene in C57BL/6 mice. PS-K and BU were found to be effective in dealing with recurrence and pulm...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3918911

データ提供：米国国立医学図書館（NLM）

Therapeutic Effects of PS-K and Busulfan on the Recurrent and Metastatic Diseases After the Surgical Removal of 3-Methylcholanthrene-Induced Autochthonous Tumors in C57BL/6 Mice

In the quest for effective cancer treatments, researchers continually explore new therapeutic strategies. This study investigated the therapeutic effects of PS-K, a protein-bound polysaccharide, and busulfan (BU), an immunoaugmenting antileukemia agent, in treating 3-methylcholanthrene-induced autochthonous tumors in C57BL/6 mice. The study aimed to determine the efficacy of these agents in preventing tumor recurrence and metastasis after surgical removal of the primary tumor.

Combating Tumor Recurrence and Metastasis: A Battle in the Desert

The study demonstrated that both PS-K and BU, when combined with surgical removal of the primary tumor, significantly prolonged survival time and reduced the incidence of local tumor recurrence. The effectiveness of these agents in treating metastasis was further supported by the extended survival time in groups of mice that did not experience local tumor recurrence. This research suggests that PS-K and BU have potential therapeutic value in managing cancer recurrence and metastasis.

A Multifaceted Approach: Navigating the Terrain of Cancer Treatment

The study emphasizes the importance of a multidisciplinary approach to cancer treatment, incorporating surgery, chemotherapy, and immunotherapy. This multifaceted approach is akin to navigating a complex desert landscape, where each element is crucial for survival. By combining different strategies, researchers can effectively combat the challenges of cancer.

Dr.Camel's Conclusion

This study provides encouraging evidence for the therapeutic potential of PS-K and busulfan in managing cancer recurrence and metastasis. The findings highlight the importance of multidisciplinary approaches to cancer treatment and underscore the ongoing need for research to explore new therapeutic strategies.
Date :
  1. Date Completed 1985-04-23
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

3918911

DOI: Digital Object Identifier

3918911

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Languages

English

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