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[Effectiveness of gnotobiotic measures in the treatment of acute leukemia: the results of a prospective randomized clinical study].

Author: AbtC, ArnoldR, DietrichM, FliednerT M, HeimpelH, HoelzerD, KubanekB, KurrleE, PfliegerH, RascheH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 60 patients with acute leukemia (AL) compared three different supportive care regimens during induction chemotherapy: strict reverse isolation with nonabsorbable antibiotics (Group A), isolation only (Group B), and routine hospital conditions (Group C). Group A had the lowest infection rate and the highest remission rate (76%), followed by Groups B (57%) and C (59%). However, there was no significant difference in survival or remission rates between the three groups after three years. The study concluded that the lack of significant benefit from isolation and decontamination was likely due to insufficient microbial suppression by the antibiotics used, and that better antimicrobial treatments should be investigated before adopting gnotobiotic care as routine support for AL patients.
Paper Details　
Original Abstract of the Article :
60 adult patients with acute leukemia (AL) previously untreated or in relapse received induction chemotherapy with different types of supportive care. Group A was decontaminated by nonabsorbable antibiotics in strict reverse isolation, group B was isolated only and group C was treated under routine ...See full text at original site
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引用元：
https://doi.org/10.1159/000214484

データ提供：米国国立医学図書館（NLM）

Gnotobiotic Measures for Acute Leukemia

This study delves into the world of acute leukemia (AL) and explores the effectiveness of gnotobiotic measures, which involve controlling the microbial environment of patients to reduce infections, as a supportive treatment. The researchers conducted a prospective randomized clinical study, a rigorous scientific approach, to evaluate the impact of different gnotobiotic measures on infection rates and remission rates in patients with AL. The findings suggest that while gnotobiotic measures may lead to fewer infections, they may not significantly improve remission rates or survival time.

Gnotobiotic Measures and Acute Leukemia

The study's results show that gnotobiotic measures may have a limited impact on the treatment of AL. While they can reduce infections, which are a significant concern for patients with compromised immune systems, they may not translate into improved outcomes in terms of remission or survival. This finding highlights the importance of evaluating different supportive care approaches for AL patients to identify those that provide the most significant benefits.

Understanding Acute Leukemia Treatment

If you or someone you know is facing a diagnosis of AL, it's essential to consult with a qualified hematologist to develop a comprehensive treatment plan. The journey through cancer treatment can be challenging, but it's important to remember that research and medical advancements continue to open new possibilities. Keep in mind that the sands of knowledge shift constantly, and we must always be open to learning and adapting our approaches to care.

Dr.Camel's Conclusion

The researchers concluded that the gnotobiotic measures used in their study did not provide a significant advantage in treating AL. They suggest that further research is needed to explore more effective antimicrobial treatments to improve the success of gnotobiotic care for patients with AL. The journey to finding the best treatments for AL is an ongoing one, and we must continue to explore new approaches and technologies to improve outcomes for patients.

Date :
  1. Date Completed 1980-03-27
  2. Date Revised 2018-02-16
Further Info :

Pubmed ID

392375

DOI: Digital Object Identifier

10.1159/000214484

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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