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Efficacy of parenteral albuterol in the treatment of asthma. Comparison of its metabolic side effects with subcutaneous epinephrine.

Author: KatzR M, RachelefskyG S, RohrA S, SiegelS C, SpectorS L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Albuterol sulfate, a bronchodilator, was found to have similar efficacy regardless of the parenteral route of administration. However, all routes of administration resulted in a clinically significant decrease in serum potassium levels, comparable to the decrease observed with epinephrine. The decrease in potassium may have important clinical implications.
Paper Details　
Original Abstract of the Article :
Three parenteral routes of albuterol sulfate were compared with placebo in their effects on serum potassium and glucose levels, heart rate, and pulmonary function in adult asthmatic subjects. In addition, the metabolic effects of subcutaneous epinephrine were compared directly with subcutaneous albu...See full text at original site
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引用元：
https://doi.org/10.1378/chest.89.3.348

データ提供：米国国立医学図書館（NLM）

Investigating the Metabolic Effects of Parenteral Albuterol in Asthma Treatment

Asthma is a chronic respiratory condition that affects millions worldwide. This study investigates the efficacy and metabolic effects of parenteral albuterol, a bronchodilator commonly used to treat asthma. The researchers compared three different routes of albuterol administration (intravenous, intramuscular, and subcutaneous) with placebo in adult asthmatic subjects.

Similar Efficacy, but Potential Potassium Concerns

The study found that all three routes of albuterol administration produced similar improvements in lung function. However, the researchers observed a significant decrease in serum potassium levels, particularly with intravenous albuterol. The magnitude of this potassium decrease was similar to that observed with a standard dose of subcutaneous epinephrine, another commonly used medication for asthma attacks.

Navigating the Balancing Act: Asthma Relief and Potential Side Effects

The findings highlight a potential trade-off. While parenteral albuterol effectively relieves asthma symptoms, it can also cause a decrease in potassium levels. This is important to consider for patients with pre-existing conditions or those taking other medications that might affect potassium levels. It’s like navigating a sandstorm in the desert – we need to be cautious of the potential risks and benefits of the path we choose to take.

Dr.Camel's Conclusion

This research emphasizes the importance of considering both the benefits and potential side effects of asthma medications. Just as a camel needs to be carefully hydrated in the desert to avoid dehydration, so too must individuals with asthma carefully monitor their potassium levels while taking parenteral albuterol.

Date :
  1. Date Completed 1986-04-08
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

3948547

DOI: Digital Object Identifier

10.1378/chest.89.3.348

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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