Penbutolol and propranolol: a comparison of their effects on antipyrine clearance in man.

Author: BaxN D, JonesR W, LennardM S, TuckerG T, WoodsH F

Paper Details 
Original Abstract of the Article :
The effects of two beta-adrenoceptor antagonists, penbutolol (administered on separate occasions as (+/-)- and (-)-forms) and propranolol, on the kinetics of antipyrine were studied in eight normal subjects. At the same degree of beta-adrenoceptor blockade, as assessed by the lowering of exercise ta...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2125.1985.tb02685.x

データ提供:米国国立医学図書館(NLM)

Penbutolol and Propranolol: A Comparison of Their Effects on Antipyrine Clearance in Man

The desert of drug metabolism is a complex landscape, with various pathways and interactions influencing how medications are processed by the body. This study investigates the effects of two beta-adrenoceptor antagonists, penbutolol and propranolol, on the clearance of antipyrine, a model drug used to assess liver function. The researchers found that propranolol significantly decreased antipyrine clearance, while penbutolol had no significant effect. These findings highlight the potential for individual variability in drug metabolism and emphasize the importance of considering individual characteristics when determining appropriate dosages.

Navigating the Desert of Drug Metabolism: Understanding Individual Differences

The study's findings suggest that different beta-adrenoceptor antagonists may have varying effects on drug metabolism. This underscores the importance of individualized medication management, taking into account factors such as liver function and specific drug interactions.

Staying Hydrated in the Desert of Medications: The Importance of Monitoring

Monitoring drug levels and adjusting dosages as needed can help ensure optimal treatment outcomes and minimize potential complications. Regular monitoring, especially for patients taking medications that affect liver function, is essential for ensuring medication safety and efficacy.

Dr. Camel's Conclusion

The desert of drug metabolism is a vast and intricate landscape, with each individual's journey through it unique. This study underscores the importance of understanding how different medications can interact with metabolic processes and the need for personalized medication management to optimize treatment outcomes and ensure safety.

Date :
  1. Date Completed 1985-07-31
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

4005101

DOI: Digital Object Identifier

10.1111/j.1365-2125.1985.tb02685.x

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